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首页> 外文期刊>The Open Anesthesiology Journal >The Effects of Glycopyrrolate as Premedication on Post-Operative Nausea and Vomiting: A Propensity Score Matching Analysis
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The Effects of Glycopyrrolate as Premedication on Post-Operative Nausea and Vomiting: A Propensity Score Matching Analysis

机译：格隆溴铵作为处方药对手术后恶心和呕吐的影响：倾向得分匹配分析

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Background: Glycopyrrolate is often used as a premedication for anesthesia as it has anti-sialogogue and vagolytic effect. Patients undergoing laparoscopic gynecologic surgery have high-risk of Post-Operative Nausea and Vomiting (PONV). Objectives: This retrospective study investigates the effect of glycopyrrolate as a premedication for PONV in patients receiving fentanyl-based Intravenous (IV) Patient-Controlled Analgesia (PCA) after laparoscopic gynecological surgery. Methods: We reviewed the medical records of adult patients who received fentanyl-based IV-PCA after laparoscopic gynecological surgery at Chung-Ang University Hospital between January 1, 2010, and June 30, 2016. We classified patients into two groups on the basis of glycopyrrolate premedication: non-premedicated group (Group N; n = 316) and glycopyrrolate premedicated group (Group P; n = 434). The Propensity Score Matching Method (PSM) was used to select 157 subjects in Group N and P, on the basis of their covariates which were matched with a counterpart in the other group. Results: Prior to PSM, the necessities for rescue anti-emetics were lower on Postoperative Day (POD) 0 (58[18.4%] vs. 45[10.4%], P = 0.002) and POD1 (60[19.0%] vs. 59[13.6%], P = 0.046), and Visual Analogue Scale (VAS) of pain on POD 1 (2.86 ± 1.49 vs. 3.13 ± 1.53, P = 0.017) was higher in group P. After PSM, the Numerical Rating Scale (NRS) score for nausea (0.38 ± 0.75 vs. 0.21 ± 0.62, P = 0.027) and rescue anti-emetics (27 [17.2%] vs. 15 [9.6%], P = 0.047) on POD 0 were both lower in the group P. Conclusion: In patients receiving fentanyl-based IV-PCA after laparoscopic gynecological surgery, the severity of nausea and necessity for rescue ant-emetic was lower in the glycopyrrolate premedication group.
机译：背景：格隆溴铵具有抗唾液酸和迷走神经的作用，因此常被用作麻醉的药物。接受腹腔镜妇科手术的患者术后恶心和呕吐（PONV）的风险较高。目的：这项回顾性研究调查了在妇科腹腔镜手术后使用格隆溴铵作为芬太尼的前药对以芬太尼为基础的静脉（IV）患者自控镇痛（PCA）患者的疗效。方法：我们回顾了2010年1月1日至2016年6月30日在中安大学医院腹腔镜妇科手术后接受以芬太尼为基础的IV-PCA的成年患者的病历。我们将患者分为两组格隆溴铵的预用药：非药物治疗组（N组; n = 316）和格隆溴铵的预治疗组（P组; n = 434）。倾向得分匹配法（PSM）用于根据N组和P组的协变量与另一组的对应变量进行选择，以选择N组和P组的157名受试者。结果：PSM之前，术后第0天（POD）0（58 [18.4％] vs. 45 [10.4％]，P = 0.002）和POD1（60 [19.0％] vs. P组中POD 1上的疼痛的视觉模拟量表（VAS）为59 [13.6％，P = 0.046]（VAS）（2.86±1.49 vs. 3.13±1.53，P = 0.017）。PSM后，数字量表POD 0的恶心（NRS）评分（0.38±0.75 vs. 0.21±0.62，P = 0.027）和救援止吐药（27 [17.2％] vs. 15 [9.6％]，P = 0.047）均较POD 0低结论：格隆溴铵处方药组在腹腔镜妇科手术后接受以芬太尼为基础的IV-PCA的患者中，恶心的严重程度和催吐药的必要性较低。

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