Alternative Splicing in Prostate and Breast Cancer

Patricia M. Watson; Dennis K. Watson

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Alternative Splicing in Prostate and Breast Cancer

机译：前列腺和乳腺癌的替代剪接

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Alternative splicing of mRNA precursors allows the synthesis of multiple mRNAs from a single primarytranscript, thus contributing to proteomic diversity in higher eukaryotes. Multiple studies demonstrate that alternativesplicing patterns are altered during cancer progression. Several different mechanisms can contribute to changes in theregulation of alternative splicing. This report will provide an overview of how splicing microarrays and large-scalesequencing are being used to identify splicing changes in breast and prostate cancer. Global analyses of splice variantshave identified cancer-specific splice variant patterns that have potential use as biomarkers and potentially haveprognostic value as well as may represent novel therapeutic targets. A description of specific splice variants withdifferential expression in these cancers and their possible functions will be presented.

机译：mRNA前体的可变剪接允许从单个初级转录本合成多个mRNA，从而有助于高级真核生物中的蛋白质组学多样性。多项研究表明，选择性分裂模式在癌症进展过程中发生了改变。几种不同的机制可导致替代剪接调控的变化。该报告将概述剪接微阵列和大规模测序如何用于鉴定乳腺癌和前列腺癌的剪接变化。对剪接变体的全局分析已鉴定出癌症潜在的剪接变体模式，这些模式可能用作生物标记物，并可能具有预后价值，并且可能代表新的治疗靶标。将介绍在这些癌症中具有差异表达的特定剪接变体及其可能功能的描述。

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《The Open Cancer Journal》 |2010年第1期|共15页
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Patricia M. Watson; Dennis K. Watson;
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1. Expression of PSA-RP2, an alternatively spliced variant from the PSA gene, is increased in prostate cancer tissues but the protein is not secreted from prostate cancer cells. [J] . Whitbread AK, Veveris Lowe TL, Dong Y, Biological chemistry . 2010,第4期

机译：PSA-RP2（一种来自PSA基因的可变剪接变体）的表达在前列腺癌组织中增加，但该蛋白并未从前列腺癌细胞中分泌。
2. Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells [J] . Elizabeth Bowler, Sean Porazinski, Simon Uzor, BMC Cancer . 2018,第1期

机译：缺氧导致PC3前列腺癌细胞的选择性剪接发生显着变化以及CLK剪接因子激酶表达升高
3. Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells [J] . Elizabeth Bowler, Sean Porazinski, Simon Uzor, BMC Cancer . 2018,第1期

机译：缺氧导致PC3前列腺癌细胞的选择性剪接发生显着变化以及CLK剪接因子激酶表达升高
4. Identification of Common and Unique Susceptibility Pathways Among Cancers of the Lung, Breast, and Prostate from Genome-Wide Association Studies and Tissue-Specific Protein Interactions [C] . David C. Qian, Jinyoung Byun, Younghun Han, International Molecular Medicine Tri-Conference. . 2015

机译：从基因组 - 宽协会研究和组织特异性蛋白质相互作用鉴定肺癌，乳腺癌和前列腺癌中共同和独特的易感性途径
5. Use and prevalence of Complementary and alternative medicine (CAM) by populations with specific needs: Patients with cancer, breast cancer, benign prostatic hyperplasia and asthma [D] . Borneman, John P. 2007

机译：特殊需要人群的补充和替代药物（CAM）的使用和流行：癌症，乳腺癌，良性前列腺增生和哮喘患者
6. Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells [O] . Elizabeth Bowler, Sean Porazinski, Simon Uzor, 2018

机译：缺氧导致PC3前列腺癌细胞的选择性剪接发生显着变化以及CLK剪接因子激酶表达升高
7. Modification of Alternative Splicing of Bcl-x Pre-mRNA in Prostate and Breast Cancer Cells [O] . Danielle R. Mercatante, Carl D. Bortner, John A. Cidlowski, 2001

机译：前列腺和乳腺癌细胞中Bcl-X前mRNA的替代剪接的修饰

Alternative Splicing in Prostate and Breast Cancer

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