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首页> 外文期刊>The Journal of Reproduction and Development >Gene Expressions in the Persistent Corpus Luteum of Postpartum Dairy Cows: Distinct Profiles from the Corpora Lutea of the Estrous Cycle and Pregnancy
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Gene Expressions in the Persistent Corpus Luteum of Postpartum Dairy Cows: Distinct Profiles from the Corpora Lutea of the Estrous Cycle and Pregnancy

机译：产后奶牛持续性黄体中的基因表达：发情周期和妊娠期黄体的不同特征

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Persistence of the corpus luteum (CL) in cattle usually occurs during the puerperium and is associated with interference of prostaglandin (PG) F2α release from the uterus. The objective of the present study was to determine for the first time the gene expressions in the persistent CL compared with the CL of pregnancy and cyclic CL. Three types of CL biopsy samples were collected from 32 lactating Holstein cows: (1) CL persisting for 29 to 33 days after the first ovulation postpartum (persistent CL, n=9), (2) CL between days 29 and 33 of early pregnancy (CL of pregnancy, n=8) and (3) CL between days 10 and 13 of the estrous cycle (cyclic CL, n=27). mRNA expression of 2',5'-oligoadenylate synthetase-1 was upregulated only in the CL of pregnancy, confirming exposure to interferon-τ (IFNT) produced by trophoblasts in pregnant cows. mRNA expressions of immune tolerance-related factors (PGES and forkhead/winged helix transcription factor 3) were upregulated in the CL of pregnancy but not in the persistent CL, suggesting that IFNT controls upregulation of these genes. mRNA expression relating to some of the major systems such as lymphangiogenesis, inflammation and apoptosis were similarly upregulated in the persistent CL and the CL of pregnancy but not in the cyclic CL. The results suggest that the persistent CL may survive for a long period without changes in local immune tolerance but develops several major systems required for CL maintenance similar to the CL of pregnancy.
机译：牛黄体（CL）的持久性通常发生在产褥期，并且与前列腺素（PG）F 2α从子宫释放的干扰有关。本研究的目的是首次确定持续性CL的基因表达与妊娠CL和周期性CL的比较。从32头泌乳的荷斯坦奶牛中收集了三种类型的CL活检样品：（1）产后第一次排卵后CL持续了29至33天（持续性CL，n = 9），（2）早孕的29至33天之间的CL （妊娠期CL，n = 8）和（3）发情周期第10天到第13天之间的CL（周期CL，n = 27）。 2'，5'-寡腺苷酸合成酶-1的mRNA表达仅在妊娠CL中被上调，证实了孕牛的滋养细胞暴露于干扰素-τ（IFNT）。免疫耐受相关因子（PGES和叉头/翅螺旋转录因子3）的mRNA表达在妊娠期CL中被上调，而在持续性CL中则不表达，这表明IFNτ控制了这些基因的上调。与某些主要系统如淋巴管生成，炎症和细胞凋亡相关的mRNA表达在持续性CL和妊娠CL中被上调，而在循环性CL中则不被上调。结果表明，持续性CL可以长期生存，而不会改变局部免疫耐受性，但会发展出一些类似于CL维持妊娠所需的主要CL维持系统。

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