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首页> 外文期刊>The Journal of Reproduction and Development >Alteration of the Endometrial EGF Profile as a Potential Mechanism Connecting the Alterations in the Ovarian Steroid Hormone Profile to Embryonic Loss in Repeat Breeders and High-producing Cows
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Alteration of the Endometrial EGF Profile as a Potential Mechanism Connecting the Alterations in the Ovarian Steroid Hormone Profile to Embryonic Loss in Repeat Breeders and High-producing Cows

机译：子宫内膜EGF谱的改变是一种潜在的机制，将卵巢类固醇激素的变化与重复育种者和高产母牛的胚胎损失联系起来

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摘要

Poor reproductive efficiency is a worldwide problem that has affected the dairy industry during the last several decades. In an attempt to explain the changes in reproductive physiology caused by high milk production, a model of elevated steroid metabolism in lactating dairy cows has been proposed. A slow increase in levels and low peak levels of estradiol (E2) and progesterone (P4) characterize endocrine changes in high producing cows. Similar changes have been reported in the repeat breeder cows. The abnormal changes in E2 and P4 concentrations of these cows may cause an improper uterine environment due to disturbed expression of growth factors and cytokines in the endometrium. This review focuses on the alteration in epidermal growth factor (EGF) profile in the endometrium during the estrous cycle. The normal cow has two peaks of EGF concentrations on days 2–4 and 13–14. Low concentrations of EGF on these days distinguished both high-producing and repeat breeder cows from normal cows. Alteration of the EGF profile could be found in 70 and 40% of the repeat breeder and high-producing cows, respectively. Treatment with a high dose of estradiol benzoate and an intravaginal progesterone-releasing device restored the normal EGF profile in about 70% of the affected cows. The cows having a normal EGF profile after treatment showed a higher pregnancy rate than the cows with the altered profile. Further studies to understand the etiology of the alteration in the EGF profile are needed to develop another treatment option and preventive management for this problem.
机译：生殖效率低下是一个全球性问题，在过去的几十年中影响了乳业。为了解释高产奶引起的生殖生理变化，提出了泌乳奶牛类固醇代谢升高的模型。雌二醇（E 2 ）和孕酮（P 4 ）的水平缓慢升高和低峰值水平是高产母牛内分泌变化的特征。在重复种牛中也有类似的变化。这些奶牛的E 2 和P 4 浓度的异常变化可能会由于子宫内膜中生长因子和细胞因子的表达紊乱而引起子宫环境不适。这篇综述的重点是在发情周期内子宫内膜的表皮生长因子（EGF）分布的变化。正常母牛在2-4天和13-14天有两个EGF浓度峰值。如今，低浓度的EGF将高产奶牛和重复种牛与正常牛区分开。 EGF谱的变化分别在70％和40％的重复育种牛和高产奶牛中发现。用高剂量的雌二醇苯甲酸酯和阴道内孕激素释放装置治疗后，约70％的受影响奶牛恢复了正常的EGF谱。治疗后具有正常EGF谱图的母牛比具有变化的谱图的母牛具有更高的妊娠率。需要进一步的研究来了解EGF谱改变的病因，以开发针对该问题的另一种治疗方案和预防措施。

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