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首页> 外文期刊>The Open Nanomedicine Journal >Zinc Oxide Nanoparticles: Therapeutic Benefits and Toxicological Hazards
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Zinc Oxide Nanoparticles: Therapeutic Benefits and Toxicological Hazards

机译：氧化锌纳米颗粒：治疗的益处和毒理学危害

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Despite the widespread application of zinc oxide nanoparticles in biomedicine, their use is still a controversial issue. Zinc oxide nanoparticles were reported to have therapeutic benefits. However, they were reported to have toxicological hazards as well. Several studies reported the antibacterial, anticancer, antioxidant, and immunomodulatory effects of zinc oxide nanoparticles. Additionally, zinc oxide nanoparticles were used in sunscreens. Furthermore, the ability to use zinc oxide nanoparticles as an adjuvant treatment to alleviate the toxic effects of chemotherapeutic drugs has been reported. However, zinc oxide nanoparticles were shown to induce toxic effects in different body organs and systems. The affected organs included liver, spleen, kidney, stomach, pancreas, heart and lung. In addition, zinc oxide nanoparticles were reported to adversely affect the neurological system, lymphatic system, hematological indices, sex hormones levels, and fetal development. The toxic effects of zinc oxide nanoparticles were based on their concentration, their dose, the route of their administration, and the time of exposure to those particles. Thus, it is crucial to assess their efficacy and safety to determine their toxicological risks and therapeutic benefits.
机译：尽管氧化锌纳米颗粒在生物医学中得到广泛应用，但其使用仍然是一个有争议的问题。据报道氧化锌纳米颗粒具有治疗益处。然而，据报道它们也具有毒理学危害。几项研究报告了氧化锌纳米颗粒的抗菌，抗癌，抗氧化和免疫调节作用。另外，氧化锌纳米颗粒被用于防晒剂中。此外，已经报道了使用氧化锌纳米颗粒作为佐剂来减轻化学治疗药物的毒性作用的能力。然而，氧化锌纳米颗粒显示出在不同的身体器官和系统中引起毒性作用。受影响的器官包括肝，脾，肾，胃，胰腺，心脏和肺。此外，据报道，氧化锌纳米粒子会对神经系统，淋巴系统，血液学指标，性激素水平和胎儿发育产生不利影响。氧化锌纳米颗粒的毒性作用取决于它们的浓度，剂量，给药途径以及与这些颗粒的接触时间。因此，评估其功效和安全性以确定其毒理学风险和治疗益处至关重要。

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