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首页> 外文期刊>The Open Drug Delivery Journal >Ion Exchange Resins as Excipients for Drug Delivery: Issues forReproducible Drug Loading
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Ion Exchange Resins as Excipients for Drug Delivery: Issues forReproducible Drug Loading

机译：离子交换树脂作为药物输送的赋形剂：可重载药物的问题

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A method for repeatable loading of propranolol hydrochloride as a model drug onto the ion exchanger AmberliteTM IRP69 was developed and different parameters for the loading process were evaluated due to their impact of the extentof loading. It was found that the extent of loading in equilibrium is widely independent of the experimental methodused. However, a magnetic stirrer comminutes the ion exchanger particles, which hampers repeatable loading processes.For kinetic studies, it was found that the pharmacopoeia dissolution tester gives best repeatable results compared to otherstirring devices (magnetic stirrer or shaking bath). Furthermore, evaluation of the loading profiles revealed complex kinetics,which can be best described by (at least) two independent processes. In addition, with different ratios between ion exchangerand propranolol, the degree of loading in the equilibrium follows an adsorption isotherm of the Langmuir type,and predicts loading capacity.
机译：开发了一种将盐酸普萘洛尔作为模型药物可重复加载到离子交换剂AmberliteTM IRP69上的方法，并且由于其对加载程度的影响，因此评估了加载过程的不同参数。已经发现，平衡中的负载程度与所使用的实验方法广泛无关。但是，磁力搅拌器会粉碎离子交换剂颗粒，从而阻碍了可重复的加载过程。为了进行动力学研究，发现药典溶出度测试仪与其他搅拌设备（磁力搅拌器或摇浴）相比具有最佳的可重复性结果。此外，对负荷曲线的评估揭示了复杂的动力学，这可以用（至少）两个独立的过程来最好地描述。另外，在离子交换剂与心得安之间的比率不同的情况下，平衡时的负载度遵循Langmuir型的吸附等温线，并预测负载容量。

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