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首页> 外文期刊>The Open Drug Delivery Journal >Preparation of Carboxymethyl-chitin Nanoparticles by Covalent Crosslinking and Their In Vitro Evaluation
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Preparation of Carboxymethyl-chitin Nanoparticles by Covalent Crosslinking and Their In Vitro Evaluation

机译：共价交联制备羧甲基壳多糖纳米粒子及其体外评价

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The degree of deacetylation and molecular weight of carboxymethyl-chitin (CM) were manipulated using 10%(w/v) NaOH aqueous solution at 25°C and 5 M HCl aqueous solution at 40°C, respectively. The resultant CMs were characterizedby 1H-NMR spectroscopy and size exclusion chromatography/multi-angle light scattering. The degree of deacetylationof 7 – 35% (mol/mol) and molecular weight of 43,000 – 449,000 were achieved. Nanoparticles were prepared usingW/O emulsification and amide coupling. Nanoparticles with the size of less than 400 nm were obtained using CMwith a high degree of deacetylation and low molecular weight, CM48-L. When the mixture of CM-mitomycin C conjugateand CM48-L underwent W/O emulsification and amide coupling, nanoparticles with the size of ca. 350 nm were obtained,and released mitomycin C fairly fast but gradually. CM with a high degree of deacetylation and low molecular weight wassuggested to be useful for the production of CM nanoparticles.
机译：分别使用25％的10％（w / v）NaOH水溶液和40°C的5 M HCl溶液控制羧甲基-几丁质（CM）的脱乙酰度和分子量。通过1 H-NMR光谱和尺寸排阻色谱/多角度光散射对所得CM进行表征。脱乙酰度为7 – 35％（mol / mol），分子量为43,000 – 449,000。使用W / O乳化和酰胺偶联制备纳米颗粒。使用具有高脱乙酰度和低分子量的CM CM48-L，可以得到尺寸小于400 nm的纳米颗粒。当CM-丝裂霉素C共轭物和CM48-L的混合物进行W / O乳化和酰胺偶联时，纳米颗粒的大小约为。获得了350 nm，并相当快但逐渐释放丝裂霉素C。高度脱乙酰基和低分子量的CM被认为可用于CM纳米颗粒的生产。

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