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首页> 外文期刊>The Open Drug Delivery Journal >Characterisation of the Ion Exchange Reaction Between Propranolol-H+ or K+ with AmberliteTM IRP 69 Resin by Both, Isothermal Titration Calorimetry and (Flame) Photometric Equilibrium Analysis
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Characterisation of the Ion Exchange Reaction Between Propranolol-H+ or K+ with AmberliteTM IRP 69 Resin by Both, Isothermal Titration Calorimetry and (Flame) Photometric Equilibrium Analysis

机译：等温滴定量热法和（火焰）光度平衡分析法对普萘洛尔H +或K +与AmberliteTM IRP 69树脂之间的离子交换反应进行表征

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The model system propranolol hydrochloride (PROP-HCl)/Amberlite? was studied in terms of equilibrium concentrations and amount drug bound to the ion exchanger, and compared to the system potassium chloride (KCl)/Amberlite?. It was found that both the affinity and exchange capacity of Amberlite? for PROP-H+ ions is higher than for K+. Specific heat effects of the exchange reaction measured by isothermal calorimetry and spectroscopy revealed that even at the lowest degree of loading with propranolol, the heat effects surprisingly change continuously with the degree of loading, while they are constant for potassium. Involvement of non-specific forces in the binding of propranolol- H+ to Amberlite? is discussed as a possible reason for this behaviour.
机译：模型系统盐酸普萘洛尔（PROP-HCl）/ Amberlite？用平衡浓度和结合到离子交换剂上的药物量研究了氯乙烯，并与氯化钾（KCl）/琥珀石体系进行了比较。发现Amberlite的亲和力和交换能力都可以吗？ PROP-H +离子的离子浓度高于K +。通过等温量热法和光谱法测量的交换反应的比热效应表明，即使在普萘洛尔负载量最低的情况下，热效应也会随着负载量的变化而连续变化，而钾的常数则恒定。非特异性作用力与普萘洛尔H +与Amberlite的结合有关吗？被讨论为这种行为的可能原因。

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