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首页> 外文期刊>The Open Dermatology Journal >A Hydroxypropyl Chitosan (HPCH) Based Medical Device Prevents Fungal Infections: Evidences from an In Vitro Human Nail Model
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A Hydroxypropyl Chitosan (HPCH) Based Medical Device Prevents Fungal Infections: Evidences from an In Vitro Human Nail Model

机译：基于羟丙基壳聚糖（HPCH）的医疗设备可预防真菌感染：来自体外人类指甲模型的证据

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摘要

A long lasting, protective and film forming HPCH-based medical device was developed and tested in a novelin vitro human nail infection model. HPCH-treated and untreated human distal fingernail fragments were disposed on theculture surface of Trychophyton rubrum, T. mentagrophytes, Scopulariopsis brevicaulis or Candida parapsilosis. Afterincubation for one or three weeks, the fragments were collected and histological analysis was performed. Results obtainedin untreated nails evidenced, as expected, that the fungal invasion was different depending on the species: it wascompleted with Trichophyton spp., partial with Scopurlariopsis sp. and limited to the surface with Candida sp.. On theother hand, HPCH-treated nails were not invaded by fungal elements, neither dermatophytes nor moulds or yeasts.Besides showing the barrier effect of HPCH this paper describes a novel in vitro model of nail infection that is simple,reproducible and closely represents the in vivo human situation.
机译：开发了一种基于HPCH的持久，保护性和成膜性医疗设备，并在新型体外人指甲感染模型中对其进行了测试。将经HPCH处理和未经处理的人类远侧指甲片段置于锥虫，毛癣菌，短柄短吻鳄或副念珠菌的培养表面。温育一或三周后，收集片段并进行组织学分析。如所预期的，未经处理的指甲获得的结果证明，真菌的侵袭因物种而异：用毛癣菌属物种完成，部分用Scopurlariopsis sp。完成。另一方面，HPCH处理过的指甲不受真菌，皮癣菌，霉菌或酵母菌的侵害。除了显示HPCH的屏障作用外，本文还描述了一种新型的指甲感染体外模型。它简单，可重现并紧密代表体内人类的情况。

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