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首页> 外文期刊>The Open Nanoscience Journal >Polyelectrolytes as Drug Carriers. Analysis by Dynamic Light Scattering of Reconstituted and in-situ Prepared Model Polymethacrylate-Drug Aqueous Dispersions
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Polyelectrolytes as Drug Carriers. Analysis by Dynamic Light Scattering of Reconstituted and in-situ Prepared Model Polymethacrylate-Drug Aqueous Dispersions

机译：聚电解质作为药物载体。重构和原位制备的聚甲基丙烯酸甲酯-药物水分散体的动态光散射分析

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This article reports dynamic light scattering (DLS) data, and electrokinetic ζ-potentials of aqueous dispersionsof two linear flexible polymethacrylic acid derivatives Eudragit?L100 (EuL) and S100 (EuS) loaded with two modeldrugs (D), lidocaine (Ld) and atenolol (At). Dispersions of EuL and EuS at 1,0 % neutralized with increasing percentages(50, 75 and 100 mole %) of each D exhibited a unimodal scattering distribution rendering diffusion coefficients (DC) inthe interval of 4 to 9. 10-9 cm2/s. All dispersions 50% neutralized exhibited quite similar DC. However, the effect of increasingneutralization followed a different pattern in each Eudragit? . All dispersions exhibited high negative ζ-potentialsthat were lower at 100% with respect to 50% loading. Both, DC and ζ-potentials, of redispersed lyophilized samples of(EuL-D) and (EuS-D) remained identical to those of in situ prepared while those of analog samples prepared by solventevaporation exhibited some slight differences. The behavior of (EuL-D) and (EuS-D) systems examined here throughDLS appears to be quite similar to that reported for polyelectrolytes neutralized with monovalent inorganic cations. Last,it has been shown that DLS provides valuable information about the reversibility from solid to dispersion states of thesenanometric drug carrier systems.
机译：本文报道了两种线性柔性聚甲基丙烯酸衍生物Eudragit？L100（EuL）和S100（EuS）的水分散液的动态光散射（DLS）数据和电动ζ电位，其中两种药物包括利多卡因（Ld）和阿替洛尔（在）。 EuD和EuS在1,0％处的分散体随D的百分比增加（50、75和100摩尔％）而被中和，表现出单峰散射分布，使得扩散系数（DC）在4至9的区间内。10-9 cm2 / s 。所有被50％中和的分散体均表现出非常相似的DC。但是，在每个Eudragit中，增加中和作用遵循不同的模式？ 。所有分散体均显示出较高的负ζ电位，相对于50％的负载量，负ζ电位在100％时较低。再分散的（EuL-D）和（EuS-D）冻干样品的DC和ζ电位都与原位制备的相同，而通过溶剂蒸发制备的类似样品的DC和ζ电位则显示出一些细微差异。这里通过DLS检查的（EuL-D）和（EuS-D）系统的行为似乎与报道的用一价无机阳离子中和的聚电解质的行为非常相似。最后，已经证明DLS提供了关于这些纳米药物载体系统从固体状态到分散状态的可逆性的有价值的信息。

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