TRPV1 in GU Disorders

Ana Charrua; AntónioAvelino; AndréSilva; Francisco Cruz

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TRPV1 in GU Disorders

机译：GU疾病中的TRPV1

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Since the first work about neuronal desensitization mediated by vanilloids, performed back in the 1970’s, majoradvances have been made in the elucidation of TRPV1 role in the genitourinary (GU) tract. The receptor distribution inthe GU tract was unveiled. Both in vivo and in vitro studies brought new insights on TRPV1 physiology. The role ofTRPV1 in bladder function in both normal and pathological states was clarified. All these data allowed the developmentof effective TRPV1 antagonists which not only confirmed the role of TRPV1 in micturition dysfunction but alsosuggested new approaches for the treatment of GU pathologies.

机译：自1970年代首次进行有关香草素介导的神经元脱敏的研究以来，在阐明TRPV1在泌尿生殖道（GU）中的作用方面取得了重大进展。揭示了GU道中的受体分布。体内和体外研究都为TRPV1生理学带来了新见解。阐明了TRPV1在正常和病理状态下在膀胱功能中的作用。所有这些数据允许开发有效的TRPV1拮抗剂，其不仅证实了TRPV1在排尿功能障碍中的作用，而且提出了治疗GU病理的新方法。

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《The Open Drug Discovery Journal》 |2010年第1期|共5页
作者
Ana Charrua; AntónioAvelino; AndréSilva; Francisco Cruz;
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中图分类药理学;
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机译：TRPV1介导anandamide的细胞摄取，从而促进内皮细胞增殖和网络形成TRPV1介导anandamide的细胞摄取，从而促进内皮细胞增殖和网络形成TRPV1介导anandamide的细胞摄取，从而促进内皮细胞增殖和网络形成。
2. Prolonged exposure to bradykinin and prostaglandin E2 increases TRPV1 mRNA but does not alter TRPV1 and TRPV1b protein expression in cultured rat primary sensory neurons [J] . Shilpa Mistry, Cleoper C Paule, Angelika Varga, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2014,第Null期

机译：长期暴露于Bradykinin和前列腺素E2增加TRPV1 mRNA，但在培养的大鼠原发性感觉神经元中没有改变TRPV1和TRPV1B蛋白表达
3. Prolonged exposure to bradykinin and prostaglandin E2 increases TRPV1 mRNA but does not alter TRPV1 and TRPV1b protein expression in cultured rat primary sensory neurons [J] . Shilpa Mistry, Cleoper C Paule, Angelika Varga, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2014,第Null期

机译：长时间暴露于缓激肽和前列腺素E2会增加培养的大鼠初级感觉神经元中TRPV1 mRNA的表达，但不会改变TRPV1和TRPV1b蛋白的表达
4. EVALUATION OF ISOTOPIC MEASUREMENTS AND BURN-UP VALUE OF SAMPLES GU3, GU3' AND BM5, BM5' OF ARIANE PROJECT [C] . Candan T?re, Alain Rodriguez, Pedro Ortego International Conference on Nuclear Criticality Safety . 2016

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5. Structural Studies on Ligand and Lipid Modulation of the Capsaicin Receptor, TRPV1 [D] . Gao, Yuan 2017

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6. Efficacy and Safety of Hou Gu Mi Xi on Spleen Qi Deficiency in Patients with Nonorganic Gastrointestinal Disorders: Protocol for a Multicenter Randomized Placebo-Controlled Trial [O] . Xiaofan Chen, Heyun Nie, Wenjun Liu, 2018

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7. Prolonged exposure to bradykinin and prostaglandin E2 increases TRPV1 mRNA but does not alter TRPV1 and TRPV1b protein expression in cultured rat primary sensory neurons [O] . Mistry, Shilpa, Paule, Cleoper C., Varga, Angelika, 2017

机译：延长暴露于缓激肽和前列腺素E2会增加TRpV1 mRNa，但不会改变培养的大鼠初级感觉神经元中TRpV1和TRpV1b蛋白的表达

TRPV1 in GU Disorders

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