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首页> 外文期刊>The Open Drug Discovery Journal >The Protective Effects of Ischemic Postconditioning against Stroke: From Rapid to Delayed and Remote Postconditioning
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The Protective Effects of Ischemic Postconditioning against Stroke: From Rapid to Delayed and Remote Postconditioning

机译：缺血性后处理对中风的保护作用：从快速到延迟和远程后处理

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The author reviews the protective effects of ischemic postconditioning, a recently emerging strategy with broadimplications in the search for new treatments in stroke and myocardial ischemic injury. Ischemic postconditioning, whichrefers to a series of brief ischemia and reperfusion cycles applied immediately at the site of the ischemic organ afterreperfusion, results in reduced infarction in both cerebral and myocardial ischemia. Conventional postconditioninginduced within a few minutes after reperfusion is arbitrarily defined as rapid postconditioning. In contrast,postconditioning performed hours to days after stroke is defined as delayed postconditioning. In addition,postconditioning can be mimicked using anesthetics or other pharmacological agents as stimuli to protect againstischemia/reperfusion injury or performed in a distant organ, which is known as remote postconditioning. In this article,the author discusses the conceptual origin of classical rapid ischemic postconditioning and its evolution into a term thatrepresents a broad range of stimuli or triggers, including delayed postconditioning, pharmacological postconditioning, andremote postconditioning. Thereafter, various in vivo and in vitro models of postconditioning and its potential protectivemechanisms are discussed. Since the concept of postconditioning is so closely associated with that of preconditioning andboth share some common protective mechanisms, whether a combination of preconditioning and postconditioning offersgreater protection than preconditioning or postconditioning alone is also discussed.
机译：作者回顾了缺血性后处理的保护作用，缺血性后处理是一种新兴的策略，在寻找中风和心肌缺血性损伤的新疗法方面具有广泛的意义。缺血后处理是指一系列短暂的缺血和再灌注周期，在再灌注后立即施加于缺血器官的部位，导致脑和心肌缺血的梗塞减少。再灌注后几分钟内引发的常规后处理被任意定义为快速后处理。相反，将中风后数小时至数天进行的后处理定义为延迟后处理。另外，可以使用麻醉药或其他药理学试剂作为刺激来模拟后处理，以防止局部缺血/再灌注损伤或在远处器官中进行，这称为远程后处理。在本文中，作者讨论了经典快速缺血性后处理的概念起源以及其演变成代表广泛刺激或触发因素的术语，包括延迟后处理，药理性后处理和远程后处理。此后，讨论了各种后处理的体内和体外模型及其潜在的保护机制。由于后处理的概念与预处理的概念紧密相关，并且两者共享一些共同的保护机制，因此还讨论了后处理和后处理的组合是否比单独进行预处理或后处理提供了更大的保护。

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