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首页> 外文期刊>The Open Drug Discovery Journal >Targeting Dopamine in Acute Traumatic Brain Injury
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Targeting Dopamine in Acute Traumatic Brain Injury

机译：靶向多巴胺治疗急性颅脑损伤

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In addition to the initial mechanical damage, traumatic brain injury (TBI) induces a series of secondary insults,such as, but not limited to, excitotoxicity, metabolic disruption, and oxidative stress. Neuroprotective strategies after TBIhave traditionally focused on cellular preservation as the measurable endpoint although multiple lines of evidence indicatethat even with significant neuronal sparing deficits remain at both the cellular and behavioral level. As such, thedevelopment of therapies that can effectively confer both neuronal sparing and post-injury functional benefit is critical toproviding the best treatment options for clinical TBI. Targeting dopaminergic signaling pathways is a novel approach inTBI that provides benefits to both neuronal survival and functional outcomes. Dopamine, like glutamate, can causeoxidative stress and significant cellular dysfunction when either depleted or over-expressed, and also plays an importantrole in central nervous system inflammation. The purpose of this review is to discuss dopamine in acute TBI and the rolethat dopaminergic therapies have as neuroprotective strategies.
机译：除最初的机械损伤外，脑外伤（TBI）还会引起一系列继发性损伤，例如但不限于兴奋性毒性，代谢破坏和氧化应激。传统上，TBI后的神经保护策略通常将细胞保存作为可测量的终点，尽管有多条证据表明，即使具有明显的神经元保留缺陷，细胞和行为水平仍然存在。因此，能够有效赋予神经元保留和损伤后功能益处的疗法的发展对于为临床TBI提供最佳治疗选择至关重要。靶向多巴胺能信号通路是TBI中的一种新方法，可为神经元存活和功能结局提供益处。像谷氨酸一样，多巴胺在耗尽或过度表达时会引起氧化应激和明显的细胞功能障碍，并且在中枢神经系统炎症中起重要作用。这篇综述的目的是讨论多巴胺在急性TBI中的作用以及多巴胺能疗法作为神经保护策略的作用。

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