Negative Regulators of the Host Response in Sepsis

Annia Maslash-Hubbard; Nidal El-wiher; Thomas P. Shanley; Timothy T. Cornell

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Negative Regulators of the Host Response in Sepsis

机译：败血症宿主反应的负调控因子

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The inflammatory response of the innate immune system to invading pathogen is complex and requires preciseregulation in order to eradicate the organism while protecting the surrounding host tissues. Two main signal transductionpathways, the NF-κB and mitogen activated protein kinase (MAPK) pathways, are activated by the invading pathogensrequiring a set of negative regulatory processes once the pathogen is eradicated. In this review we focus on three keynegative regulatory processes: intracellular inhibitors, regulatory phosphatases and epigenetic mechanisms.

机译：先天免疫系统对入侵病原体的炎症反应非常复杂，需要精确调节才能消灭生物体，同时保护周围的宿主组织。病原体一旦消灭，入侵的病原体会激活两个主要的信号转导途径，即NF-κB和促分裂原活化的蛋白激酶（MAPK）途径。在这篇综述中，我们着眼于三个关键的负调控过程：细胞内抑制剂，调控磷酸酶和表观遗传机制。

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《The Open Inflammation Journal》 |2011年第1期|共6页
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Annia Maslash-Hubbard; Nidal El-wiher; Thomas P. Shanley; Timothy T. Cornell;
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中图分类炎症;
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1. Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response [J] . SrivastavS., KarS., ChandeA.G., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2012,第2期

机译：Leishmania donovani利用宿主去泛素化酶A20（TLR信号的负调节剂）破坏宿主的免疫反应
2. Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis [J] . Chao Ding, Jack Yang, Cornelis van’t Veer, Intensive Care Medicine Experimental . 2019,第1期

机译：缓激肽受体缺乏或拮抗作用不会影响革兰氏阴性肺炎衍生败血症的宿主反应
3. Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis [J] . Chao Ding, Jack Yang, Cornelis van’t Veer, Intensive Care Medicine Experimental . 2019,第1期

机译：缓激肽受体缺乏或拮抗作用不会影响革兰氏阴性肺炎衍生败血症的宿主反应
4. Metal-Organic Framework Enhanced Cellular and Humoral Immune Response Against Sepsis Causing Infection [C] . Michael Luzuriaga, Nicole J De Nisco, Jeremiah J Gassensmith Pacific Rim Meeting on Electrochemical and Solid-State Science . 2020

机译：金属有机骨架增强了对脓毒症引起感染的细胞和体液免疫应答
5. Siglec-G is a negative regulator of NF-kB activation and has pivotal roles in B-1 cell development and resistance to sepsis. [D] . Ding, Cheng. 2008

机译：Siglec-G是NF-kB激活的负调节剂，在B-1细胞发育和对败血症的抵抗中起关键作用。
6. Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis [O] . Chao Ding, Jack Yang, Cornelis van’t Veer, 2019

机译：缓激肽受体缺乏或拮抗作用不会影响革兰氏阴性肺炎衍生败血症期间的宿主反应
7. Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis [O] . Chao Ding, Jack Yang, Cornelis van’t Veer, 2019

机译：Bradykinin受体缺乏或拮抗作用在革兰氏阴性肺炎衍生的败血症期间不会影响宿主反应
8. Effect of Endotoxemia and Gram-Negative Sepsis on Host Peripheral Granulocyte Endogenous Chemiluminescence [R] . McCarthy, J. P., Bodroghy, R. S., Sobocinski, P. Z. 1981

机译：内毒素血症和革兰阴性脓毒症对宿主周围粒细胞内源性化学发光的影响

Negative Regulators of the Host Response in Sepsis

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