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首页> 外文期刊>The Open Inflammation Journal >Pediatric Sepsis: Markers, Mechanisms, and Management
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Pediatric Sepsis: Markers, Mechanisms, and Management

机译：小儿败血症：标记，机制和管理

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摘要

Sepsis is a significant health problem in both critically ill children and adults. While the mortality rate from sepsis is much lower in children, sepsis is directly responsible for over 4,000 childhood deaths per year in the UnitedStates alone. At face value, this number suggests that more children die per year in the United States from sepsis as theprimary cause than from cancer. Unfortunately, there are few studies on the epidemiology, pathophysiology, andmanagement of sepsis in children. Moreover, extrapolation of adult data to critically ill children is probably notappropriate due to several key developmental differences in the host response to infection and response to therapy.Therefore, additional studies targeting sepsis in the pediatric population are urgently required.
机译：败血症在重症儿童和成人中都是重要的健康问题。尽管儿童败血症的死亡率要低得多，但仅在美国，败血症就直接导致每年4000多例儿童死亡。从表面上看，这个数字表明，美国每年因败血症为主要死因的儿童多于死于癌症的儿童。不幸的是，关于儿童流行病学，病理生理学和败血症的管理的研究很少。此外，由于宿主对感染和治疗反应的几个关键发展差异，将成人数据外推到重症儿童可能不合适，因此，迫切需要针对儿童败血症的其他研究。

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