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首页> 外文期刊>The Open Infectious Diseases Journal >No Long-Term Risk for Increased Spread of PNSP in Day-Care Centres by Permitting Carriers to Remain in the Day-Care Centre Group
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No Long-Term Risk for Increased Spread of PNSP in Day-Care Centres by Permitting Carriers to Remain in the Day-Care Centre Group

机译：通过允许承运人保留在日托中心组中，PNSP在日托中心中传播的增加不会产生长期风险

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摘要

In a 6-year prospective epidemiological intervention study the spread of pneumococci non-susceptible to penicillin(PNSP) was studied among children attending day-care centres (DCCs). A primary aim was to investigate whetherthere was a risk for spread of PNSP by permitting children carrying PNSP strains to remain in the DCC. Carriers were followeduntil they presented negative cultures. The PNSP strains were characterised by serotyping, antibiotic susceptibilitytesting and clonality. Thirteen children with PNSP, initiated sampling of 321 children, 66 DCC personnel and 149 familymembers. Twenty-three (7 %) asymptomatic carriers were identified but none among the personnel. The most spread serotypewas 6B (47%), followed by 19F (17%) and 9V (14%). The PNSP isolates were resistant to three antibiotics ormore (69%). The spreading capability and duration of carriage differed between PNSP clones but no long-term risk for increasedspread of PNSP in DCCs by carriers was found.
机译：在一项为期6年的前瞻性流行病学干预研究中，研究了在日托中心（DCC）的儿童中对青霉素（PNSP）不敏感的肺炎球菌的传播。一个主要目的是通过允许携带PNSP毒株的儿童留在DCC中，调查是否存在PNSP传播的风险。跟踪载体，直到它们呈现出负面文化。 PNSP菌株的特征在于血清分型，抗生素敏感性测试和克隆性。十三名患有PNSP的儿童，对321名儿童，66名DCC人员和149名家庭成员进行了抽样调查。确定了二十三名（7％）无症状携带者，但人员中没有。分布最广的血清型是6B（47％），其次是19F（17％）和9V（14％）。 PNSP分离株对三种或更多种抗生素具有抗药性（69％）。 PNSP克隆之间的传播能力和运输时间不同，但未发现携带者在DCC中增加PNSP传播的长期风险。

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