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首页> 外文期刊>The Open Obesity Journal >A Possible Role for Chemerin; a Novel Adipokine in the Haemostatic andAtherogenic Disorders Related to Obesity in White Albino Rats
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A Possible Role for Chemerin; a Novel Adipokine in the Haemostatic andAtherogenic Disorders Related to Obesity in White Albino Rats

机译：Chemerin的可能作用;肥胖相关的白色白化病大鼠的止血和致动脉粥样硬化疾病中的新型脂肪因子。

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A strong link between obesity, hypercoagulability and thrombogenesis, had been recognized. Chemerin is anovel adipokine that has been activated by the coagulation process and suggested to play an important role in thepathogenesis of metabolic syndrome. We aimed to identify the possible relationship between chemerin levels andhaemostatic changes in the high fat diet (HFD) fed rats. A total number of 20 adult male albino rats were divided into twogroups of 10 rats each. Group I, rats served as controls; Group II: rats received high fat diet (58% fat) for 8 weeks. In bothgroups, serum levels of glucose, insulin, chemerin, total cholesterol (TC), triglycerides (TG), HDL, LDL were measured.As well as the bleeding time (BT), whole blood clotting time (WBCT), Prothrombin time (PT), Activated partialthromboplastin time (aPTT), fibrinogen level and C- reactive protein (CRP) were measured. Moreover HOMA-IR wascalculated for both groups. The results of the current study revealed that chemerine level increased significantly in theHFD- fed rats (p< 0.001). In addition, a significant positive correlation was detected for the serum chemerin levels withbody weight, insulin levels, HOMA-IR, the levels of TC, TG, LDL and CRP, while a significant negative correlation wasfound between its levels and serum levels of HDL. Moreover chemerin was correlated negatively with the BT, WBCT,PT, aPTT and positively correlated with plasma fibrinogen, while there was insignificant correlation with platelet count.These results suggested that chemerin may represent a novel link between obesity and its haemostatic and atherogeniccomplication.
机译：人们已经认识到肥胖，高凝和血栓形成之间的紧密联系。 Chemerin是一种已经被凝血过程激活的阳极脂肪脂因子，被认为在代谢综合征的发病机制中起着重要的作用。我们旨在确定高脂饮食（HFD）喂养的大鼠中chemerin水平与止血变化之间的可能关系。将总共​​20只成年雄性白化病大鼠分成两组，每组10只。第一组，大鼠为对照组。第二组：大鼠接受高脂饮食（58％脂肪）持续8周。两组均测量血清葡萄糖，胰岛素，凯莫瑞，总胆固醇（TC），甘油三酸酯（TG），HDL，LDL的水平，以及出血时间（BT），全血凝固时间（WBCT），凝血酶原时间（ PT），活化的部分凝血活酶时间（aPTT），纤维蛋白原水平和C反应蛋白（CRP）。此外，计算两组的HOMA-IR。当前研究的结果表明，在以HFD喂养的大鼠中，凯莫瑞水平显着增加（p <0.001）。此外，血清凯莫瑞水平与体重，胰岛素水平，HOMA-IR，TC，TG，LDL和CRP水平呈显着正相关，而其水平与血清​​HDL水平呈显着负相关。此外，chemerin与BT，WBCT，PT，aPTT呈负相关，与血浆纤维蛋白原呈正相关，而与血小板计数无显着相关。这些结果表明chemerin可能代表了肥胖与其止血和动脉粥样硬化并发症之间的新联系。

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