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首页> 外文期刊>The Open Obesity Journal >Signalling Pathways Implicated in Obesity Associated Cancers
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Signalling Pathways Implicated in Obesity Associated Cancers

机译：肥胖相关癌症中涉及的信号通路

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Intensive research over recent years has provided irrefutable evidence of links between obesity and the risk ofan increasing number of human cancers. The predicted economic burden is causing significant concern. This hasprompted investigation of the underlying mechanisms with a focus on deregulated metabolic pathways. A number ofmetabolic processes and associated signalling pathways are associated with the development of obesity. These include anumber of interlinking pathways regulating endocrine, redox, inflammation, immunity and lipogenic processes. Theidentification of deregulated metabolic pathways in obesity with promotion of carcinogenesis has targeted research on thesignalling molecules involved. Consequently this mini review is focused on aberrant signalling of deregulated pathwaysprovoked by diets that lead to obesity and their role in carcinogenesis. Knowledge of the signalling molecules involvedwill assist in directing and establishing dietary manipulation strategies to restore metabolic health in obese individuals.Importantly the identified diversity of signalling pathways linked to obesity related cancers will permit design of moreeffective combinatorial and multi-targeted cancer therapies in the future.
机译：近年来的深入研究提供了肥胖与越来越多的人类癌症风险之间的联系的确凿证据。预计的经济负担引起了人们的极大关注。这促进了对潜在机制的研究，重点是失控的代谢途径。许多代谢过程和相关的信号传导途径与肥胖症的发展有关。这些包括调节内分泌，氧化还原，炎症，免疫力和脂肪形成过程的许多相互联系的途径。肥胖中致癌作用促进的代谢途径失控的鉴定已经针对涉及信号分子的研究进行了研究。因此，本小型综述的重点是饮食引起的异常途径的异常信号传导，这些饮食导致肥胖及其在致癌作用中的作用。了解有关信号分子的知识将有助于指导和建立饮食控制策略以恢复肥胖个体的代谢健康。重要的是，与肥胖相关的癌症相关的信号通路的多样性将使未来设计更有效的组合和多靶点癌症疗法成为可能。

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