Galactofuranosylated Galactocerebrosides, a New Drug Delivery System for Ceramides to Colon

Dumitru Petru Iga; Silvia Iga

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Galactofuranosylated Galactocerebrosides, a New Drug Delivery System for Ceramides to Colon

机译：半乳糖呋喃糖基化的半乳糖苷，一种新的神经酰胺向结肠的药物递送系统

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Two isomeric partially acetylated galactocerebrosides, ?-D-galactopyranosyl (2,3,4-tri-O-acetyl)- and ?-Dgalactopyranosyl (2,4,6-tri-O-acetyl)-1’(3’-O-acetyl)ceramide, were prepared from galactocerebroside and sulfatide, respectively. Their galactofuranosylation produced ?-D-galactofuranosyl-6- and ?-D-galactofuranosyl-3-?-Dgalactopyranosyl- 1’ceramide, as demonstrated by 1H and 13C NMR spectra as well as by chemical means.

机译：部分异构化的部分乙酰化的半乳糖脑苷，α-D-吡喃半乳糖苷（2,3,4-三-O-乙酰基）-和α-吡喃半乳糖苷（2,4,6-三-O-乙酰基）-1'（3'-O -乙酰基）神经酰胺分别由半乳糖脑苷和硫化物制备。 1H和13C NMR光谱以及化学方法证明，他们的半乳糖呋喃糖基化反应可生成β-D-半乳糖呋喃糖基-6-和β-D-半乳糖醛糖基-3-β-吡喃并吡喃糖基-1′神经酰胺。

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《The Open Organic Chemistry Journal》 |2008年第1期|共6页
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Dumitru Petru Iga; Silvia Iga;
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中图分类有机化学;
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2. A novel dissolution media for testing drug release from a nanostructured polysaccharide-based colon specific drug delivery system: an approach to alternative colon media [J] . Niranjan G Kotla, Sima Singh, Balaji Maddiboyina, International Journal of Nanomedicine . 2016,第3期

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4. Polymer mixtures as colon targeted drug delivery systems [C] . Mario Helmis, Mont Kumpugdee-Vollrath International Conference on Manufacturing Science and Engineering . 2013

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5. The development and evaluation of systemic drug delivery systems for C6-ceramide as a breast cancer chemotherapeutic agent. [D] . Stover, Thomas C. 2005

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6. A novel dissolution media for testing drug release from a nanostructured polysaccharide-based colon specific drug delivery system: an approach to alternative colon media [O] . Niranjan G Kotla, Sima Singh, Balaji Maddiboyina, 1988

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Galactofuranosylated Galactocerebrosides, a New Drug Delivery System for Ceramides to Colon

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