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首页> 外文期刊>The Open Obesity Journal >Triglyceride Concentration is Independently Associated with Variation inthe LPL Gene in African American and European American Women
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Triglyceride Concentration is Independently Associated with Variation inthe LPL Gene in African American and European American Women

机译：甘油三酯浓度与非裔美国人和欧美妇女的LPL基因变异独立相关

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摘要

Objective: The regulation of triglyceride (TG) metabolism may be affected by many factors including:race/ethnicity, body composition, body fat distribution, insulin action, and the activity of the lipoprotein lipase (LPL)enzyme. This study was designed to identify the independent effects of body composition, body fat distribution, insulinaction, and LPL genetic variation on TG and HDL-C concentration. Subjects: The study consisted of premenopausalEuropean American (EA) (n=114) and African American (AA) (n=140) women. Measurements: Body composition wasmeasured by dual-energy X-ray absorptiometry (DXA), intra-abdominal adipose tissue (IAAT) by computed tomography(CT), insulin sensitivity (SI) and the acute insulin response to glucose (AIRg) by intravenous glucose tolerance test,median household income by zip-code. An estimate of individual genetic admixture was obtained from the genotyping of85 ancestry informative markers and used to control for population stratification. Multiple linear regression analyses wereused to identify contributions of body composition, IAAT, SI, AIRg, African genetic admixture, and LPL polymorphismsto TG and HDL-C. Results: AA had lower TG and higher HDL-C than EA. African genetic admixture, IAAT, AIRg, SI,and RS285 were significantly and independently related to TG concentration. SI was the only independent contributor toHDL-C. RS1800590 was not associated with variation in TG or HDL. Conclusion: Triglyceride concentration appears tobe multifactorial in origin and emanates in part from variance in LPL RS285. Future investigations are necessary tounderstand the mechanisms through which gene polymorphisms, body fat distribution, and insulin action influence thelipid profile.
机译：目的：甘油三酸酯（TG）代谢的调节可能受许多因素影响，包括种族/民族，身体组成，体内脂肪分布，胰岛素作用以及脂蛋白脂肪酶（LPL）酶的活性。这项研究旨在确定体成分，体脂肪分布，胰岛素作用和LPL遗传变异对TG和HDL-C浓度的独立影响。受试者：该研究由绝经前的欧美（EA）（n = 114）和非裔美国人（AA）（n = 140）妇女组成。测量：通过双能X线吸收法（DXA），计算机断层扫描（CT），腹腔内脂肪组织（IAAT），胰岛素敏感性（SI）和静脉内葡萄糖对胰岛素的急性胰岛素反应（AIRg）测量身体成分容忍度测试，家庭邮政编码中位数家庭收入。从85个祖先信息标记的基因分型中获得了单个遗传混合物的估计值，并用于控制种群分层。使用多元线性回归分析来确定人体成分，IAAT，SI，AIRg，非洲遗传混合物以及TG和HDL-C的LPL多态性的贡献。结果：AA比EA具有更低的TG和更高的HDL-C。非洲遗传混合物，IAAT，AIRg，SI和RS285与TG浓度显着且独立相关。 SI是HDL-C的唯一独立贡献者。 RS1800590与TG或HDL的变化无关。结论：甘油三酸酯浓度似乎是多因素起源的，部分源于LPL RS285的差异。有必要进行进一步的研究，以了解基因多态性，体内脂肪分布和胰岛素作用影响脂质分布的机制。

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