• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Open Obesity Journal >Molecular Mechanisms of Obesity, Inflammation and Cancer: The Use of in vitro Model Approaches for Targeted Prevention Strategies
【24h】

Molecular Mechanisms of Obesity, Inflammation and Cancer: The Use of in vitro Model Approaches for Targeted Prevention Strategies

机译：肥胖，发炎和癌症的分子机制：体外模型方法在靶向预防策略中的应用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hormones, growth factors and cytokines produced by adipocytes are associated with cancer progression. We suggest that chronically elevated adipokines as observed in the obese state may have profound effects locally on colon epithelial cells through growth promotion effects, induction of autocrine signaling, angiogenesis and immune cross-talk. This dysregulation of the local environment via a systemic signal may lead to the promotion of colon cancer via a novel set of mechanisms. Elucidating the mechanisms by which obesity may increase cancer risk may lead to the identification of treatment/prevention targets. The use of models of this multistage process should allow for mechanism-based approaches to block phenotypes associated with the process of carcinogenesis. The review highlights using in vitro model systems of these various stages to understand the molecular mechanisms of obesity and cancer risk. The advantage in using these systems is that the response of cells possessing various transformations can be compared to “normal cells”. The key is to identify targets that are aberrant from normal to perturb for cancer prevention strategies. This approach would theoretically reduce the possibility of severe or unwanted side-effects when the target does not also destroy the normal cell mechanisms. Cell models can aid in the identification of those targets and inform rationale translation to animal and human studies.
机译：脂肪细胞产生的激素，生长因子和细胞因子与癌症进展有关。我们建议在肥胖状态下观察到的慢性升高的脂肪因子可能通过生长促进作用，自分泌信号传导，血管生成和免疫串扰对结肠上皮细胞局部产生深远影响。通过系统性信号对局部环境的这种失调可能通过一套新颖的机制导致结肠癌的发展。阐明肥胖可能增加癌症风险的机制可能导致确定治疗/预防目标。这种多阶段过程的模型的使用应该允许基于机制的方法来阻断与致癌过程相关的表型。该综述重点介绍了使用这些不同阶段的体外模型系统来了解肥胖和癌症风险的分子机制。使用这些系统的优势在于，可以将具有各种转化的细胞的响应与“正常细胞”进行比较。关键是要确定从正常到扰动的癌症预防策略目标。当靶标也不会破坏正常细胞机制时，这种方法理论上将减少发生严重或不良副作用的可能性。细胞模型可以帮助识别这些靶标，并为动物和人类研究提供理论依据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号