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首页> 外文期刊>The Open Obesity Journal >12-Week Behavioral Lifestyle Modification Program Increases BloodAntioxidant Enzyme Activities in Obese Adults
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12-Week Behavioral Lifestyle Modification Program Increases BloodAntioxidant Enzyme Activities in Obese Adults

机译：12周行为生活方式改变计划增加肥胖成年人的血液抗氧化酶活性

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This study aims to evaluate the outcome of a 12-week behavioral lifestyle modification program focusing onthe blood oxidative stress levels/activities in obese subjects and aims to examine the association between the changes inblood oxidative stress levels/activities and modifications in serum lipid profile concentrations. An interventional studywas conducted involving thirty-four obese adults, all of whom were recruited from the Obesity Clinic, Hospital UniversitiSains Malaysia. The subjects participated in the 12-week behavioral lifestyle modification program consisting of diet andexercise interventions. Blood was obtained from the subjects at baseline (week 0) and after 12 weeks (week 13) for thedetermination of oxidative stress levels/activities and lipid profile concentrations. Plasma glutathione peroxidase (GPx)activity and 4-hydroxynonenal (4-HNE) level increased significantly, and the ratio of reduced glutathione (GSH) tooxidized glutathione (GSSG) was decreased following 12-week interventions. Other enzymatic antioxidant activities suchas catalase (CAT) and superoxide dismutase (SOD) were increased, but the changes were not statistically significant.Changes in plasma GPx activity were negatively correlated with changes in serum triglyceride (TG) andVLDL-cholesterol concentrations. In conclusion, diet and exercise interventions in the 12-week behavioral lifestylemodification program were effective in increasing antioxidant enzyme activities in obese adults.
机译：这项研究旨在评估针对肥胖受试者血液氧化应激水平/活性的为期12周的行为生活方式改变计划的结果，并旨在检查血液氧化应激水平/活性的变化与血清脂质谱浓度变化之间的关联。进行了一项干预性研究，涉及34名肥胖成年人，所有这些成年人都是从马来西亚大学医院的肥胖诊所招募的。受试者参加了为期12周的行为生活方式改善计划，其中包括饮食和运动干预。在基线时（第0周）和12周后（第13周）从受试者获得血液，以测定氧化应激水平/活性和脂质分布浓度。经过12周的干预，血浆谷胱甘肽过氧化物酶（GPx）活性和4-羟基壬烯（4-HNE）水平显着增加，还原型谷胱甘肽（GSH）与氧化型谷胱甘肽（GSSG）的比例降低。其他酶抗氧化活性如过氧化氢酶（CAT）和超氧化物歧化酶（SOD）增加，但变化无统计学意义。血浆GPx活性变化与血清甘油三酸酯（TG）和VLDL-胆固醇浓度呈负相关。总之，在为期12周的行为生活方式改变计划中的饮食和运动干预可有效增加肥胖成年人的抗氧化酶活性。

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