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首页> 外文期刊>The Open Pain Journal >TRP Receptors in Arthritis, Gaining Knowledge for Translation fromExperimental Models
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TRP Receptors in Arthritis, Gaining Knowledge for Translation fromExperimental Models

机译：关节炎中的TRP受体，从实验模型中获取翻译知识

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Arthritis is a condition characterised by mainly pain, reduced joint movement and signs of inflammation, suchas swelling. The disorder has many different types, of which osteoarthritis (a degenerative joint disease) and rheumatoidarthritis (a chronic autoimmune disease) are the two most common forms. There are >6 million sufferers in the UK andboth conditions have a huge potential to impair capabilities and contribute to social and economic burdens. Whilst thereare a wide range of arthritic therapies available, many patients under treatment complain of poor pain relief. Thus there isa need for novel therapeutic approaches, and the transient receptor potential (TRP) family of receptor channels has beeninvestigated. One particular area of recent research has been the ligand-gated transient receptor potential vanilloid 1(TRPV1) channel. Findings from numerous pre-clinical models and scientific studies have shown that TRPV1 desensitisation,or the use of TRPV1 antagonists alleviates pain and some inflammatory aspects. New findings have started to unveilthe potential of other TRP channels in mediating arthritic pain and inflammation. With the understanding that the currentlyavailable treatments for arthritis are limited, researchers have looked into the exciting prospect that TRP receptorantagonists may be developed into effective, specific drugs, which would potentially protect against the complications ofarthritis. These antagonists are still under development, although only data from studies from pre-clinical models are currentlyavailable. This review acts to summarize knowledge of the potential influence of TRP receptors in arthritis to date.
机译：关节炎是一种主要以疼痛，关节运动减少和炎症迹象（例如肿胀）为特征的疾病。该疾病有多种类型，其中骨关节炎（一种退行性关节疾病）和类风湿关节炎（一种慢性自身免疫性疾病）是两种最常见的形式。在英国，有超过600万的患者，而且这两种情况都有极大的潜力削弱能力并加重社会和经济负担。尽管有各种各样的关节炎疗法可用，但许多接受治疗的患者抱怨疼痛缓解不佳。因此，需要新颖的治疗方法，并且已经研究了受体通道的瞬时受体电位（TRP）家族。最近研究的一个特定领域是配体门控瞬时受体电位香草酸1（TRPV1）通道。来自大量临床前模型和科学研究的结果表明，TRPV1脱敏或使用TRPV1拮抗剂可缓解疼痛和某些炎症。新发现开始揭示其他TRP通道在介导关节炎疼痛和炎症中的潜力。认识到目前对关节炎的治疗方法有限，研究人员已经将TRP受体拮抗剂发展成为有效的，特异性的药物，从而有可能预防关节炎的并发症，这令人振奋。尽管目前只有来自临床前模型的研究数据，但这些拮抗剂仍在开发中。这篇综述的作用是总结迄今为止对TRP受体在关节炎中潜在影响的认识。

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