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首页> 外文期刊>The Open Pain Journal >A Systematic Review with Meta-analysis of Studies Comparing Response to Experimentally-evoked Pain Between Obese and Non-Obese Individuals
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A Systematic Review with Meta-analysis of Studies Comparing Response to Experimentally-evoked Pain Between Obese and Non-Obese Individuals

机译：荟萃分析的系统评价，对肥胖和非肥胖个体对实验诱发疼痛的反应进行比较

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Background: The relationship between obesity and pain remains unclear. The aim of this systematic review was to determine whether response to experimentally-evoked pain differed between obese and non-obese individuals. Studies that compared responses to experimentally-evoked pain between obese and non-obese human participants post-puberty (i.e. 16 years) were sought. Eligible studies published between January 1950 and May 2017 were identified by searching OVID, MEDLINE, EMBASE and Science Direct. Explanation: Methodological quality of included studies was assessed using the ‘QualSyst’ questionnaire. Of 1106 references identified only nine studies (683 participants) were eligible for review. Pressure pain was assessed in five studies and electrical pain in three studies. Two studies investigated thermal pain. Obesity was categorized according to body mass index (BMI) or as weight as a percentage of ideal body weight. Six of the nine included studies were of low methodological quality. There was a lack of extractable data to pool for meta-analysis of studies using thermal or electrical pain. A forest plot of data extracted from four studies on pressure pain threshold found no differences between obese and non-obese groups (overall effect size was Z=0.57, p=0.57). Conclusion: Small sample size was the main limitation in all studies. Participants with obesity were more sensitive to mechanical noxious stimuli than non-obese participants in three of five studies. However, overall, it was not possible to determine whether there are differences in pain sensitivity response to experimental stimuli between obese and non-obese individuals.
机译：背景：肥胖与疼痛之间的关系尚不清楚。这项系统评价的目的是确定肥胖者和非肥胖者对实验诱发的疼痛的反应是否不同。寻求研究比较青春期后（即> 16岁）肥胖和非肥胖参与者对实验诱发的疼痛的反应。通过搜索OVID，MEDLINE，EMBASE和Science Direct确定了1950年1月至2017年5月之间发表的合格研究。说明：纳入研究的方法学质量是使用“ QualSyst”问卷进行评估的。在确定的1106篇参考文献中，只有9篇研究（683名参与者）有资格进行审查。五项研究评估了压痛，三项研究评估了电痛。两项研究调查了热痛。肥胖症是根据体重指数（BMI）或体重占理想体重的百分比进行分类的。九项纳入研究中的六项方法学质量较低。缺乏可提取的数据来汇总使用热或电痛进行的研究的荟萃分析。从四项关于压力疼痛阈值的研究中提取的森林数据中，肥胖组和非肥胖组之间没有差异（总体影响量为Z = 0.57，p = 0.57）。结论：小样本量是所有研究的主要限制。在五项研究中的三项中，肥胖的参与者比非肥胖的参与者对机械有害刺激更为敏感。然而，总的来说，不可能确定肥胖者和非肥胖者在对实验刺激的疼痛敏感性反应中是否存在差异。

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