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首页> 外文期刊>The Open Pathology Journal >Therapy-Induced Morphological Alterations in Brain Tumors
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Therapy-Induced Morphological Alterations in Brain Tumors

机译：治疗诱导的脑肿瘤形态学改变

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Routine therapeutic options for tumors of the brain or spinal cord comprise surgery, radiation and/orchemotherapy, all of which are associated with several possible complications. The most important consequences of braintumor therapy are hemorrhage, acute brain swelling with external herniation of parts of the brain, CSF leaks, andcoagulopathies. The anatomical location of surgical manipulation may have additional special effects, like diabetesinsipidus following pituitary or adjacent base of the brain surgery. New techniques of radiotherapy applied in neurooncologysuch as “gamma knife” (stereotactic radiosurgery), intracavital brachytherapy, three dimensional conformalradiation, are also associated with iatrogenic changes in the brain. Pathologic changes induced by various radiotherapeuticmodalities are discussed in this review, with special emphasis on terminology, timing and the importance ofpathologic examination for assessing the tumor response to therapy, signs of peritumoral tissue damage and tumorrecurrence. Therapy-induced secondary neoplastic lesions are also discussed.
机译：脑或脊髓肿瘤的常规治疗选择包括手术，放射和/或化学疗法，所有这些都与几种可能的并发症相关。脑瘤治疗最重要的后果是出血，急性脑肿胀和部分脑外突出，CSF渗漏和凝血病。外科手术的解剖学位置可能具有其他特殊作用，例如脑垂体或邻近脑外科手术后的糖尿病。神经肿瘤学中应用的放射治疗新技术，例如“伽马刀”（立体定向放射外科手术），腔内近距离放射治疗，三维共形放射，也与大脑的医源性变化有关。在这篇综述中讨论了由各种放射治疗方式引起的病理变化，特别着重于术语，时机和病理学检查在评估肿瘤对治疗反应，肿瘤周围组织损伤迹象和肿瘤复发的重要性。还讨论了治疗引起的继发性肿瘤性病变。

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