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Histopathology of Colorectal Cancer after Neoadjuvant Chemoradiation Therapy

机译:新辅助化学放疗后结直肠癌的组织病理学

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Neoadjuvant treatment has become the standard of care for locally advanced gastrointestinal carcinoma, hence,the pathologist increasingly encounters treated primary and metastatic colorectal tumors. The pathologic assessment oftherapeutic response and evaluation of residual disease is important because the histologic response to therapy or tumorresponse grade (TRG) has been shown to correlate with survival. Therefore, it is important for the pathologist to befamiliar with the changes seen in colorectal cancer and metastatic colorectal cancer after neoadjuvant therapy. This reviewdiscusses the treatment effects seen in colon, rectal and liver resections including lymph nodes and the evaluation ofresidual tumor tissue in these specimens.
机译:新辅助治疗已成为局部晚期胃肠道癌的治疗标准,因此,病理学家越来越多地遇到已治疗的原发性和转移性结直肠肿瘤。治疗反应的病理学评估和残留疾病的评估非常重要,因为已显示出对治疗的组织学反应或肿瘤反应等级(TRG)与生存相关。因此,重要的是病理学家要熟悉新辅助治疗后在结直肠癌和转移性结直肠癌中所见的变化。这篇综述讨论了在结肠,直肠和肝脏切除术(包括淋巴结)中观察到的治疗效果以及这些标本中残余肿瘤组织的评估。

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