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首页> 外文期刊>The Open Medicinal Chemistry Journal >Prodrugs of NSAIDs: A Review
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Prodrugs of NSAIDs: A Review

机译：非甾体抗炎药的前药：审查。

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Intoroduction:Prodrug approach deals with chemical biotransformation or enzymatic conversion or involves inactive or less active bio-reversible derivatives of active drug molecules. They have to pass through enzymatic or chemical biotransformation before eliciting their pharmacological action.Methods & Materials:The two different pharmacophores combine to give synergistic activity or may help in targeting the active drug to its target. Prodrug super seeds the problems of prodrug designing, for example solubility enhancement, bioavailability enhancement, chemical stability improvement, presystemic metabolism, site specific delivery, toxicity masking, improving patient acceptance, or eradicating undesirable adverse effects.Results:As an outcome the search for a prodrug or mutual prodrug with reduced toxicity has continued during recent years. This present review emphasizes the common help to revamp physiochemical, pharmaceutical and therapeutic effectiveness of drugs.Conclusion:This gives the researcher a common platform where they can find prodrugs of commonly used NSAIDs to overcome the gastrointestinal toxicity (irritation, ulcergenocity and bleeding).
机译：信息诱导：前药方法涉及化学生物转化或酶促转化，或涉及活性药物分子的非活性或活性较低的生物可逆衍生物。在获得药理作用之前，它们必须经过酶促或化学生物转化。方法和材料：两种不同的药效基团结合起来具有协同活性，或可能有助于将活性药物靶向其靶标。前药超级植入了前药设计的问题，例如溶解度提高，生物利用度提高，化学稳定性提高，全身代谢，部位特异性传递，毒性掩蔽，改善患者接受度或消除不良不良反应等结果。近年来，毒性降低的前药或互用前药一直在继续。本综述着重介绍了改善药物的理化，药物和治疗效果的通用帮助。结论：这为研究人员提供了一个通用平台，在平台上，他们可以找到常用的NSAID的前药来克服胃肠道毒性（刺激性，溃疡性和出血性）。

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