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首页> 外文期刊>The Open Pediatric Medicine Journal >Sacrosidase Trial in Chronic Nonspecific Diarrhea in Children
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Sacrosidase Trial in Chronic Nonspecific Diarrhea in Children

机译：cro糖苷酶试验在儿童慢性非特异性腹泻中的应用

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摘要

Chronic nonspecific diarrhea in children, or toddler’s diarrhea, is a frequently encountered entity in pediatricclinical practice. This disorder remains poorly understood. Suggested etiologies include malabsorption, dietary intake andmotility abnormalities. We investigated the use of sacrosidase (a yeast sucrase supplement) in children with toddler’s diarrhea.The study outcome was clinical response to sacrosidase supplementation. Children, 1-6 years of age, with toddler’sdiarrhea were enrolled in an open prospective trial. Stooling patterns were obtained at baseline and while on supplementation.Twelve patients were enrolled out of 40 patients who presented with chronic diarrhea. Eight patients did not respondto standard diet changes and were entered into the trial. With supplementation, 4 out of the 8 patients responded clinicallywith a decrease in mean daily stool frequency and an improvement in the mean daily stool consistency. Sacrosidase supplementationdemonstrated a potential benefit in a subset of children with toddler’s diarrhea. Response to sacrosidase maysuggest excessive sucrose intake or unrecognized partial or complete sucrase deficiency in some children with toddler’sdiarrhea.
机译：儿童的慢性非特异性腹泻或幼儿的腹泻是儿科临床实践中经常遇到的问题。这种疾病仍然知之甚少。建议的病因包括吸收不良，饮食摄入和运动异常。我们研究了sa糖苷酶（酵母糖蔗糖补充剂）在幼儿腹泻儿童中的应用。研究结果是对sa糖苷酶的临床反应。一项1-6岁的幼儿腹泻的儿童参加了一项开放性前瞻性试验。在基线时和补充时获得了粪便模式。40例慢性腹泻患者中有12例入选。八名患者对标准饮食改变没有反应，被纳入试验。补充后，8例患者中有4例在临床上有反应，平均每日大便次数减少，平均每日大便稠度提高。补充糖苷酶证明对部分腹泻儿童具有潜在的益处。对sa糖苷酶的反应可能建议某些幼儿腹泻的儿童摄入过多的蔗糖或未认识到部分或完全蔗糖缺乏症。

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