• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Open Pediatric Medicine Journal >Distinguishing Environmental Causes of Immune Dysfunction fromPediatric Triggers of Disease
【24h】

Distinguishing Environmental Causes of Immune Dysfunction fromPediatric Triggers of Disease

机译：区分小儿疾病引发的免疫功能障碍的环境原因

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many pediatric diseases are linked to underlying immune dysfunction that produces problematic responses to common infectious challenges and other conditions. During childhood, immune dysfunction manifests as: 1) increased susceptibility to certain infections, 2) misregulated inflammation with tissue damage, fatigue and secondary infections, 3) autoimmune disease and 4) allergic conditions. Both environmental and genetic risk factors contribute to a variety of pediatric immune-related illnesses. Ironically, the environmental risk factors are usually considered as one large continuum of equivalent chemical, physical and emotional factors spanning the entirety of a child’s development. But the reality is that some prenatal and neonatal environmental factors are most likely to cause the underlying pediatric immune dysfunction necessary for inflammatory, autoimmune and allergic disease. In contrast, other childhood environmentalfactors are usually triggers that activate or challenge the dysfunctional immune system leading directly to disease. Exposure to these triggers represents a final step in the overall disease process. Knowledge of both the causative agents for immune dysfunction as well as the triggering factors is important. However, viewing these prenatal and childhood factors as one continuum of risk is not always helpful. These distinct groups of environmental factors need to be recognized separately if prevention of immune dysfunction and management of immune-based diseases are to be optimized. This mini-review provides a unifying hypothesis concerning causative environmental factors vs triggering events for several important pediatric diseases. Improved recognition of these different steps should help pediatricians to better address these diseases.
机译：许多儿科疾病与潜在的免疫功能障碍有关，后者会对常见的传染病和其他疾病产生难以解决的反应。在儿童时期，免疫功能障碍表现为：1）对某些感染的敏感性增加; 2）组织损伤，疲劳和继发感染引起的炎症调节失调; 3）自身免疫性疾病; 4）过敏性疾病。环境和遗传风险因素均导致多种儿科免疫相关疾病。具有讽刺意味的是，环境风险因素通常被认为是跨越儿童整个发育过程的相当大的等效化学，物理和情感因素的连续体。但是现实情况是，某些产前和新生儿环境因素最有可能引起炎症，自身免疫和过敏性疾病所必需的潜在的小儿免疫功能障碍。相反，其他儿童期环境因素通常是激活或挑战功能异常的免疫系统的诱因，直接导致疾病。接触这些诱因代表整个疾病过程的最后一步。了解免疫功能障碍的病因和触发因素很重要。但是，将这些产前和儿童时期的因素视为一种风险连续体并不总是有帮助的。如果要优化预防免疫功能障碍和管理基于免疫的疾病，则需要分别识别这些不同的环境因素。这份小型综述提供了有关致病性环境因素与几种重要儿科疾病触发事件的统一假设。更好地认识这些不同的步骤应有助于儿科医生更好地解决这些疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号