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Cardiogenic Shock

机译:心源性休克

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摘要

The primary function of the cardiovascular system is to provide oxygen and energy substrates to the body'stissues. In all forms of shock, there is metabolic failure - a downstream consequence of an inability to meet the metabolicdemands of the tissue. In cardiogenic shock, the primary derangement leading to unmet tissue metabolic demands iscardiac dysfunction. Though cardiac impairment may be implicated in other categories of shock, primary cardiac failure inthe form of cardiogenic shock is the third most common type of shock in pediatrics – trailing septic shock andhypovolemic shock. Myocardial malfunction, in other forms of shock, is secondary to ischemia, acidosis, drugs, toxins, ordirect myocardial depressants due to inflammation. Cardiogenic shock, a low-output state, is characterized by elevatedventricular filling pressures, low cardiac output, systemic hypotension, and evidence of end-organ hypoperfusion. Herein,we will highlight the pathophysiology of cardiogenic shock, the various causative etiologies, the multitude of laboratoryor imaging diagnostic options, current advances in therapies, and outcomes in patients.
机译:心血管系统的主要功能是为人体的组织提供氧气和能量的底物。在所有形式的休克中,都会出现新陈代谢衰竭,这是无法满足组织新陈代谢需求的下游结果。在心源性休克中,导致未满足组织代谢需求的主要紊乱是心脏功能障碍。尽管心脏功能障碍可能与其他类型的休克有关,但以心源性休克为形式的原发性心力衰竭是小儿第三大最常见的休克类型,即败血性休克和低血容量性休克。在其他形式的休克中,心肌功能衰竭是继发于缺血,酸中毒,药物,毒素或因炎症而直接引起的心肌抑制药。心源性休克是一种低输出状态,其特征是心室充盈压升高,心输出量低,全身性低血压和终末器官灌注不足的证据。在这里,我们将重点介绍心源性休克的病理生理学,各种病因,多种实验室或影像学诊断选择,当前的治疗进展以及患者的预后。

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