Androgen Receptor Expression and Function in Osteoclasts

R.A.Davey; A.J. Notini; W.S.M. Chiu; J. Hodge; G. Nicholson; J.D. Zajac; A.G.Turner

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Androgen Receptor Expression and Function in Osteoclasts

机译：破骨细胞中雄激素受体的表达和功能

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We assessed androgen receptor (AR) expression in osteoclasts in vitro and in situ. Rat multinucleated osteoclastsexpressed detectable AR protein in situ, and AR mRNA was detected in mouse and human derived osteoclast-likecells in vitro. Dihydrotestosterone treatment did not affect human osteoclast-like cell formation or resorption in vitro.

机译：我们评估了体外和原位破骨细胞中雄激素受体（AR）的表达。大鼠多核破骨细胞原位表达可检测的AR蛋白，并在小鼠和人来源的破骨细胞样细胞中检测到AR mRNA。双氢睾酮治疗不影响人破骨细胞样细胞的形成或体外吸收。

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《The Open Physiology Journal》 |2008年第1期|共6页
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R.A.Davey; A.J. Notini; W.S.M. Chiu; J. Hodge; G. Nicholson; J.D. Zajac; A.G.Turner;
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中图分类生理学;
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1. Ectopic expression of the amino-terminal peptide of androgen receptor leads to androgen receptor dysfunction and inhibition of androgen receptor-mediated prostate cancer growth. [J] . Minamiguchi K, Kawada M, Ohba S, Molecular and Cellular Endocrinology . 2004,第1a2期

机译：雄激素受体氨基末端肽的异位表达导致雄激素受体功能障碍并抑制雄激素受体介导的前列腺癌的生长。
2. 957 Ectopic expression of the amino-terminal peptide of androgen receptor leads to androgen receptor dysfunction and inhibition of androgen receptor-mediated prostate cancer growth [J] . K.Minamiguchi, M.Kawada, S.Ohba, European Journal of Cancer Supplements . 2003,第5期

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3. Associations of saposin C, Src, and androgen receptor upregulate the expression and function of androgen receptor in human prostate cancer cells. [J] . Ding Y, Wang X, Xu A, Journal of cellular biochemistry. . 2011,第3期

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4. Expression of Estrogen a and p Variants, Androgen, and Progesterone Receptors in Human Normal and Neoplastic Endometrium [C] . Maciej Skrzypczak, Sylwia Zagulska-Szymczak, Rosette Lidereau, International Symposium on Hormonal Carcinogenesis . 2005

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5. MED19 Alters Genomic Occupancy of the Androgen Receptor and Gene Expression in Prostate Cancer Cells, Driving Growth under Low Androgen [D] . Weber, Hannah. 2020

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7. Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement. : Androgen receptor and TRPM8 in human prostate apical epithelial cells [O] . Bidaux Gabriel, Roudbaraki Morad, Merle Corinne, 2005

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Androgen Receptor Expression and Function in Osteoclasts

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