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首页> 外文期刊>The Open Physiology Journal >The Metabolic Syndrome of ω3-Depleted Rats.IX. Food Intake
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The Metabolic Syndrome of ω3-Depleted Rats.IX. Food Intake

机译：ω3耗竭大鼠的代谢综合症。食物的摄入量

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The present study complements recent investigations on the changes in fatty acid content and pattern of liverphospholipids and triglycerides found in ω3-depleted rats which, when exposed for 2 weeks to a flaxseed oil-enricheddiet, display aggravated liver steatosis, visceral obesity and excess body weight. In the present experiments, the ω3-depleted rats exposed to the flaxseed oil-enriched diet still displayed insulin resistance, with higher plasma glucose andinsulin concentrations than in control animals undergoing the same dietary manipulations. The food intake and gain inbody weight after the switch in diet were also higher in the ω3-depleted rats than in control animals exposed for the sameperiod to either soybean or flaxseed oil-enriched diets, there being a close analogy between these two variables in the 3groups of rats. Emphasis is placed on the orexigenic effect attributable to the brain accumulation of C22:5ω3 andC22:6ω3, on the flaxseed dietary self-selection in the ω3-depleted rats, and on the increase in the lipid content of the dietfrom 5 to 10% (w/w) as possible determinants of the increase in food intake. In a clinical perspective, these findings indicatethat, when considering the most suitable dietary approach to correct a deficiency in long-chain polyunsaturated ω3fatty acids, equal attention should be paid to the lipid and ω3 fatty acid content of the diet, as well as to food intake, in orderto avoid undesirable increases in adipose tissue mass and body weight.
机译：本研究是对ω3耗竭大鼠中脂肪酸含量和肝磷脂和甘油三酸酯模式变化的最新研究的补充，ω3耗竭大鼠中亚麻籽油摄入饮食2周后，其表现为肝脂肪变性加重，内脏肥胖和体重过重。在本实验中，暴露于富含亚麻籽油的饮食的ω3耗竭大鼠仍表现出胰岛素抵抗，血浆葡萄糖和胰岛素浓度高于接受相同饮食操作的对照动物。在ω3耗竭的大鼠中，饮食转换后的食物摄入和体重增加也比相同时期暴露于大豆或富含亚麻籽油的饮食中的对照动物要高，这两个变量之间存在相似的关系。 3组大鼠。重点放在因C22：5ω3和C22：6ω3的大脑积聚而引起的致食作用，对ω3耗竭大鼠中亚麻籽饮食的自我选择以及饮食中脂质含量从5％增加到10％（ w / w）可能是决定食物摄入量增加的因素。从临床角度来看，这些发现表明，当考虑最合适的饮食方法来纠正长链多不饱和ω3脂肪酸的不足时，应同等注意饮食中的脂质和ω3脂肪酸含量为了避免脂肪组织质量和体重的不期望的增加。

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