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首页> 外文期刊>The Open Tropical Medicine Journal >The Possible Protective Role of the Il6-174GC Genotype in Dengue Fever
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The Possible Protective Role of the Il6-174GC Genotype in Dengue Fever

机译：Il6-174GC基因型在登革热中可能的保护作用

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Dengue is the most important viral disease transmitted by arthropod vectors. At present, it is known four typesof virus serotypes, DEN 1, 2, 3 and 4. Differences in the host susceptibility to infection as well as the severity of diseasecan not be due only to viral virulence. Variations in immune response as a consequence of polymorphisms in regulatoryregions of cytokine genes may have influence on the disease outcome. The aim of this study was to verify the occurrenceof associations between cytokine gene polymorphisms and Dengue Fever. Two hundred patients from Paraná State and313 control individuals from Southern and Southeastern Brazil were genotyped for single nucleotide polymorphisms(SNPs) of TNF-308, IFNG+874, IL6-174, IL10-1082,-819,-592 and TGFB1+869,+915 by PCR-SSP (kits One Lambda, CA, USA).Phenotype, genotype and allele frequencies were compared by chi-square test, with Yates’ correction or Fisher’s exacttest. There was a negative association between IL6-174GC genotype and Dengue Fever (27.9% vs. 38.3%; P=0.015;OR=0.62; CI=0.42 - 0.91). Significant statistical differences with cytokine production phenotypes or alleles were notobserved. These results suggest a protective role of IL6-174GC genotype for Dengue Fever.
机译：登革热是节肢动物媒介传播的最重要的病毒性疾病。目前，已知四种病毒血清型，DEN 1、2、3和4。宿主对感染的易感性以及疾病的严重程度的差异不仅仅是由于病毒的毒性。细胞因子基因调控区域多态性导致的免疫应答变化可能会影响疾病的预后。这项研究的目的是验证细胞因子基因多态性与登革热之间的关联的发生。对来自巴拉那州的200名患者和来自巴西南部和东南部的313名对照个体进行了TNF-308，IFNG + 874，IL6-174，IL10-1082，-819，-592和TGFB1 + 869单核苷酸多态性（SNP）基因分型， PCR-SSP +915（美国加利福尼亚州One Lambda药厂）。通过卡方检验比较表型，基因型和等位基因频率，并进行Yates校正或Fisher精确检验。 IL6-174GC基因型与登革热之间呈负相关（27.9％对38.3％; P = 0.015; OR = 0.62; CI = 0.42-0.91）。没有观察到与细胞因子产生表型或等位基因的显着统计学差异。这些结果表明IL6-174GC基因型对登革热具有保护作用。

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