...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Thoracic cancer. >Identification of lung adenocarcinoma mutation status based on histologic subtype: Retrospective analysis of 269 patients
【24h】

Identification of lung adenocarcinoma mutation status based on histologic subtype: Retrospective analysis of 269 patients

机译：基于组织学亚型的肺腺癌突变状态识别：269例患者的回顾性分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AbstractBackgroundTo evaluate differences in the clinical characteristics and molecular pathology of lung adenocarcinoma subtypes as defined by the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international histological classification.MethodsWe retrospectively reviewed 269 patients with initial primary lung adenocarcinoma who had undergone complete resection at our department from August 2013 to December 2014, focusing on the new histologic subtype classification, clinical characteristics, and molecular pathology.ResultsAll specimens were invasive adenocarcinoma, and were lepidic (13.0%), papillary (19.7%), acinar (51.7%), solid (8.6%), micropapillary (1.1%) or mucinous predominant (5.9%). Epidermal growth factor receptor (EGFR) mutations were detected in 132 cases (60.3%). Female patients and non-smokers had higher EGFR mutation rates (P = 0.022 and 0.026, respectively). The lepidic, papillary, acinar, solid, micropapillary, and mucinous predominant patterns had EGFR mutation rates of 70.6%, 64.8%, 72.5%, 33.3%, 100%, and 5.9%, respectively. The exon mutation distribution differed according to serum carcinoembryonic antigen (CEA) levels (P = 0.018). v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations were detected in 20 cases (9.2%), and were frequently found in the mucinous and solid predominant subtypes. The serum CEA levels differed among the subtypes.ConclusionsIn China, there are significant differences between lung adenocarcinoma histologic subtypes. The presence of well-differentiated components in lung adenocarcinoma indicates higher EGFR mutation rates; the presence of solid or mucinous components indicates higher KRAS mutation rates. Serum CEA levels are associated with histologic subtype and EGFR exon mutations.
机译：摘要背景为了评估新的国际肺癌研究协会/美国胸科学会/欧洲呼吸学会国际组织学分类所定义的肺腺癌亚型的临床特征和分子病理学差异，方法我们回顾性回顾了269例原发性原发性肺腺癌患者2013年8月至2014年12月在我科行全切除术，重点关注新的组织学亚型分类，临床特征和分子病理学检查。 （51.7％），固体（8.6％），微乳头（1.1％）或黏液性为主（5.9％）。在132例病例中检测到表皮生长因子受体（EGFR）突变（60.3％）。女性患者和非吸烟者的EGFR突变率更高（分别为P = 0.022和0.026）。鳞状，乳头状，腺泡状，实心，微乳头状和粘液状为主的模式的EGFR突变发生率分别为70.6％，64.8％，72.5％，33.3％，100％和5.9％。外显子突变的分布因血清癌胚抗原（CEA）水平而异（P = 0.018）。 v-Ki-ras2克尔斯滕大鼠肉瘤病毒癌基因同源物（KRAS）突变检测到20例（9.2％），并经常发现在粘液和固体为主的亚型中。血清CEA水平在亚型之间有所差异。结论在中国，肺腺癌组织学亚型之间存在显着差异。肺腺癌中高分化成分的存在表明较高的EGFR突变率。固体或粘液成分的存在表明更高的KRAS突变率。血清CEA水平与组织学亚型和EGFR外显子突变有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号