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首页> 外文期刊>Thoracic cancer. >Malignant pleural mesothelioma: A retrospective analysis of clinicopathological and survival data
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Malignant pleural mesothelioma: A retrospective analysis of clinicopathological and survival data

机译：恶性胸膜间皮瘤：临床病理和生存数据的回顾性分析

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Background: The aim of this study was to analyze the clinicopathological features of malignant pleural mesothelioma (MPM) and evaluate the therapeutic measures offered to patients with MPM and their impact on survival.Methods: Data was retrospectively collected from the medical records of 304 patients who presented to the Department of Clinical Oncology and Nuclear Medicine, Ain Shams University between January 2003 and December 2008.Results: The mean age of patients was 52.1 years (range 24–87 years). One hundred and ninety patients (62.5%) came from endemic areas and/or gave history of occupational asbestos exposure. One hundred and sixty-nine patients received chemotherapy. There was a significant difference between the median survival for patients who received chemotherapy (9 months, 95% CI 7.69–10.30) and those who were offered best supportive care (2 months, 95% CI 0.09–3.91). Other factors that affected the survival negatively were: non-epithelial pathology (P= 0.001); age 50 years (P= 0.012); bad performance status (P= 0.001); non-platinum based chemotherapy (P= 0.0001); and progressive disease (P= 0.000). Cox regression analysis revealed that the factors that predicted shorter survival were patients being offered best supportive care rather than chemotherapy and progressive disease.Conclusion: MPM is a growing health problem in Egypt that needs more attention. The current analysis of data reflects the importance of maintaining a high index of suspicion to allow for early diagnosis, especially for cases that live in areas with high asbestos exposure and for people who work in occupations that expose them to asbestos as well as their family members. Prospective randomized trials comparing multimodality approaches to other forms of treatment and including quality of life assessment are warranted.
机译：背景：本研究的目的是分析恶性胸膜间皮瘤（MPM）的临床病理特征，并评估为MPM患者提供的治疗措施及其对生存的影响。方法：从304例患者的病历中回顾性收集数据。于2003年1月至2008年12月间，将其报告给Ain Shams大学临床肿瘤与核医学系。结果：患者的平均年龄为52.1岁（24-87岁）。 190位患者（62.5％）来自地方病区和/或有职业性石棉接触史。 169例患者接受了化疗。接受化疗的患者（9个月，95％CI 7.69–10.30）与接受最佳支持治疗的患者（2个月，95％CI 0.09–3.91）的中位生存期之间存在显着差异。影响生存的其他因素包括：非上皮病理（P = 0.001）;年龄> 50岁（P = 0.012）;不良的表现状态（P = 0.001）;非铂类化疗（P = 0.0001）;和进行性疾病（P = 0.000）。 Cox回归分析显示，预测生存期较短的因素是为患者提供了最佳的支持治疗，而不是化疗和进行性疾病。结论：MPM是埃及日益严重的健康问题，需要引起更多关注。当前对数据的分析反映了保持高度怀疑的指数以进行早期诊断的重要性，特别是对于居住在石棉暴露量高的地区的病例以及从事将其暴露于石棉的职业的人及其家庭成员而言。必须进行前瞻性随机试验，将多模式方法与其他形式的治疗方法进行比较，包括生活质量评估。

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