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Resveratrol and Diabetes

机译：白藜芦醇和糖尿病

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Resveratrol is a stilbene compound, and a phytoalexin, synthesized by plants in response to stressful stimuli, usually caused by infection. It is abundantly present in red wine, ports and sherries, red grapes, blueberries, peanuts, itadori tea, as well as hops, pistachios, and in grape and cranberry juices. The anti-hyperglycemic effects of resveratrol seem to be the result of an increased action of the glucose transporter in the cytoplasmic membrane. Studies on rats with streptozotocin-induced diabetes have demonstrated that the expression of the insulin-dependent glucose transporter, GLUT4, is increased after resveratrol ingestion. Also, resveratrol enhances adiponectin levels, which could be one of the potential mechanisms by which it improves insulin sensitivity. Another important observation is that resveratrol induces the secretion of the gut incretin hormone, glucagon-like peptide-1. Resveratrol is also reported to activate Sir2 (silent information regulatory 2), a SIRT1 homolog, thus mimicking the benefits of calorie restriction. It produces a wide variety of effects in mammalian cells, including activation of AMP-activated protein kinase, which is involved in some of the same metabolic pathways as SIRT1, which may influence other mechanisms via the involvement of nuclear factor kappa B (NF-κB). In the near future, resveratrol-based therapies with either resveratrol or its analogs that have better bioavailability could be useful in the treatment of diabetes and its complications, either alone or in combination with other anti-diabetic drugs.
机译：白藜芦醇是一种二苯乙烯化合物和一种植物抗毒素，由植物响应于通常由感染引起的应激刺激而合成。它广泛存在于红酒，港口和雪利酒，红葡萄，蓝莓，花生，Itadori茶，啤酒花，开心果以及葡萄和酸果蔓汁中。白藜芦醇的降血糖作用似乎是葡萄糖转运蛋白在细胞质膜中作用增强的结果。对链脲佐菌素诱发的糖尿病大鼠的研究表明，摄取白藜芦醇后，胰岛素依赖性葡萄糖转运蛋白GLUT4的表达增加。此外，白藜芦醇可增强脂联素水平，这可能是其改善胰岛素敏感性的潜在机制之一。另一重要观察结果是白藜芦醇可诱导肠降血糖素激素胰高血糖素样肽1的分泌。据报道，白藜芦醇还可以激活SIRT1同源物Sir2（沉默信息调节2），从而模拟了限制卡路里的益处。它在哺乳动物细胞中产生多种作用，包括激活AMP活化的蛋白激酶，与SIRT1参与某些相同的代谢途径，这可能通过核因子κB（NF-κB）的参与影响其他机制。 ）。在不久的将来，以白藜芦醇或其类似物具有更好生物利用度的白藜芦醇为基础的疗法可单独或与其他抗糖尿病药物联合用于糖尿病及其并发症的治疗。

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