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首页> 外文期刊>Therapeutics and Clinical Risk Management >The association study of high-sensitivity C-reactive protein, pentraxin 3, nitrotyrosine, and insulin dose in patients with insulin-treated type 2 diabetes mellitus
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The association study of high-sensitivity C-reactive protein, pentraxin 3, nitrotyrosine, and insulin dose in patients with insulin-treated type 2 diabetes mellitus

机译：胰岛素治疗的2型糖尿病患者中高敏C反应蛋白，五价毒素3，硝基酪氨酸和胰岛素剂量的相关性研究

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Purpose: The objective of this study was to examine the association between insulin dose and high-sensitivity C-reactive protein (hsCRP), nitrotyrosine, and pentraxin 3 in patients with insulin-treated type 2 diabetes. Patients and methods: Eighty patients with type 2 diabetes treated with insulin for >6 months and with stable insulin doses (±10%) within 3 months before inclusion were enrolled in this study. Medical history, including use of insulin and insulin doses, concomitant diseases and medication, and anthropometric and routine biochemical parameters were collected for each patient. hsCRP, nitrotyrosine, and pentraxin 3 were measured in fasting conditions. Comparison analysis was performed according to the distribution in tertiles of insulin dose/kg of body weight, and linear regression adjusted for confounding factors was used to examine the associations between markers of inflammation, oxidative stress, and insulin dose. Results: In the comparison analysis, no statistically significant difference was found between hsCRP, nitrotyrosine, and pentraxin 3 levels across tertiles of insulin dose expressed as IU/kg of body weight ( p for trend >0.05 for all comparisons) except a significantly higher hsCRP level in tertile 3 compared to tertile 1 (3.9±3.6 vs 6.1±3.8 mg/dL, p =0.035). In regression analysis, after adjustment for age, gender, smoking, body mass index, glycated hemoglobin, C-peptide, metformin, antiplatelet, and statin use, only hsCRP levels were statistically significant associated with insulin dose/kg of body weight ( β =0.237, p =0.043). Conclusion: In this sample of patients with type 2 diabetes treated with insulin for >6 months, hsCRP was positively associated with insulin doses. No such association was found for pentraxin 3, a more specific marker of vascular inflammation, and for nitrotyrosine as a marker of oxidative stress.
机译：目的：本研究的目的是检查胰岛素治疗的2型糖尿病患者的胰岛素剂量与高敏C反应蛋白（hsCRP），硝化酪氨酸和戊五醇3之间的关系。患者和方法：纳入本研究的80例2型糖尿病患者，接受胰岛素治疗> 6个月，并在入选前3个月内使用稳定的胰岛素剂量（±10％）。收集每位患者的病史，包括使用胰岛素和胰岛素的剂量，伴随的疾病和用药以及人体测量学和常规生化参数。在禁食条件下测量了hsCRP，硝基酪氨酸和五笔毒素3。根据胰岛素剂量/ kg体重在三分位数中的分布进行比较分析，并针对混杂因素调整线性回归以检查炎症标志物，氧化应激和胰岛素剂量之间的关联。结果：在比较分析中，胰岛素剂量的三分位数之间的hsCRP，硝化酪氨酸和五环素3水平在IU / kg体重之间均无统计学上的显着差异（所有比较的趋势p> 0.05），但hsCRP明显更高三分位数3与三分位数1的水平比较（3.9±3.6 vs 6.1±3.8 mg / dL，p = 0.035）。在回归分析中，在调整了年龄，性别，吸烟，体重指数，糖化血红蛋白，C肽，二甲双胍，抗血小板和他汀类药物的使用后，只有hsCRP水平与胰岛素剂量/ kg体重有统计学意义（β= 0.237，p = 0.043）。结论：在接受胰岛素治疗超过6个月的2型糖尿病患者中，hsCRP与胰岛素剂量呈正相关。没有发现五聚体蛋白3（一种更具体的血管炎症标志物）和硝基酪氨酸作为氧化应激的标志物的这种关联。

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