...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Therapeutic advances in gastroenterology. >Association between physical activity and risk of nonalcoholic fatty liver disease: a meta-analysis
【24h】

Association between physical activity and risk of nonalcoholic fatty liver disease: a meta-analysis

机译：体育活动与非酒精性脂肪肝风险之间的关联：一项荟萃分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Increased physical activity (PA) is a key element in the management of patients with nonalcoholic fatty liver disease (NAFLD); however, its association with NAFLD risk has not been systematically assessed. This meta-analysis of observational studies was to quantify this association with dose–response analysis. Electronic databases were searched to January 2017 for studies of adults reporting the risk of NAFLD in relation to PA with cohort or case-control designs. Studies that reported sex-specific data were included as separate studies. The overall risk estimates were pooled using a random-effects model, and the dose–response analysis was conducted to shape the quantitative relationship. A total of 6 cohort studies from 5 articles with 32,657 incident NAFLD cases from 142,781 participants, and 4 case-control studies from 3 articles with 382 NAFLD cases and 302 controls were included. Compared with the lowest PA level, the highest PA level was associated with a risk reduction of NAFLD in cohort [RR (risk ratio) 0.79, 95% CI (confidence interval) 0.71–0.89] and case-control studies [OR (odds ratio) 0.43, 95% CI 0.27–0.68]. For cohort studies, both highest and moderate PA levels were superior to the light one in lowering NAFLD risk (pfor interaction = 0.006 and 0.02, respectively), and there was a log-linear dose–response association (pfor nonlinearity = 0.10) between PA and NAFLD risk [RR 0.82 (95% CI 0.73–0.91) for every 500 metabolic equivalent (MET)-minutes/week increment in PA]. Increased PA may lead to a reduced risk of NAFLD in a dose-dependent manner, and the current guideline-recommended minimum PA level that approximates to 500 MET-minutes/week is able to moderately reduce the NAFLD risk.
机译：运动量增加（PA）是非酒精性脂肪肝（NAFLD）患者管理中的关键要素;但是，其与NAFLD风险的关联尚未得到系统评估。这项观察性研究的荟萃分析旨在量化这种与剂量反应分析的关联。检索到2017年1月的电子数据库，以研究报告有队列或病例对照设计的NAFLD与PA相关的风险的成年人。报告性别特定数据的研究也作为单独的研究纳入。使用随机效应模型汇总总体风险估计，并进行剂量反应分析以建立定量关系。包括来自142781名参与者的32 657例NAFLD病例的5篇文章的6项队列研究，以及来自382例NAFLD的302例对照的3篇文章的4项病例对照研究。与最低PA水平相比，最高PA水平与队列中NAFLD的风险降低相关[RR（风险比）0.79、95％CI（置信区间）0.71-0.89]和病例对照研究[OR（几率） ）0.43，95％CI为0.27-0.68]。在队列研究中，最高和中等的PA水平在降低NAFLD风险方面均优于轻水平的PA（相互作用的p 分别为0.006和0.02），并且剂量-反应相关性呈对数线性关系PA与NAFLD风险之间的差异（p 非线性 = 0.10）[PA中每500分钟代谢当量（MET）分钟/周增加RR 0.82（95％CI 0.73–0.91）。 PA升高可能导致剂量依赖性的NAFLD风险降低，目前指南建议的最低PA水平约为500 MET分钟/周，能够适度降低NAFLD风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号