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首页> 外文期刊>The Review of Diabetic Studies : RDS >Review of the Diabetes Heart Study (DHS) Family of Studies: A Comprehensively Examined Sample for Genetic and Epidemiological Studies of Type 2 Diabetes and its Complications
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Review of the Diabetes Heart Study (DHS) Family of Studies: A Comprehensively Examined Sample for Genetic and Epidemiological Studies of Type 2 Diabetes and its Complications

机译：糖尿病心脏研究（DHS）家族研究的综述：2型糖尿病及其并发症的遗传和流行病学研究的全面检查样本

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The Diabetes Heart Study (DHS) is a genetic and epidemiological study of 1443 European American and African American participants from 564 families with multiple cases of type 2 diabetes. Initially, participants were comprehensively examined for measures of subclinical cardiovascular disease (CVD) including computed tomography measurement of vascular calcified plaque, ultrasound imaging of carotid artery wall thickness, and electrocardiographic intervals. Subsequent studies have investigated the relationship between bone mineral density and vascular calcification, measures of adiposity, and biomarkers. Ongoing studies are carrying out an extensive evaluation of cerebrovascular disease using magnetic resonance imaging and cognitive assessment. A second, parallel study, the African American DHS, has expanded the sample of African Americans to investigate marked racial differences in subclinical CVD between European Americans and African Americans. Studies in development will evaluate the impact of social stress during the lifecourse on CVD risk, and the prevalence of gastroparesis in this diabetes enriched sample. In addition, the ongoing high mortality rate in DHS participants provides novel insights into the increased risks for type 2 diabetes affected individuals. A comprehensive genetic analysis of the sample is underway using the genome-wide association study (GWAS) approach. Data from this GWAS survey will complement prior family-based linkage data in the analysis of genetic contributors to the wide range of traits in the sample. To our knowledge the DHS family of studies has created the most comprehensively examined sample of individuals with type 2 diabetes yet available, and represents a unique resource for the study people with type 2 diabetes. The aim of this review is to provide a collective overview of the major results from the DHS family of studies, and relate them to the larger body of biomedical investigations of diabetes and its complications.
机译：糖尿病心脏研究（DHS）是一项遗传和流行病学研究，研究对象是来自564个家庭的2443例多发病例的1443名欧美人。最初，对参与者进行了全面的亚临床心血管疾病（CVD）测量，包括对血管钙化斑块进行计算机X线断层扫描测量，对颈动脉壁厚度进行超声成像以及心电图检查间隔。随后的研究调查了骨矿物质密度与血管钙化，脂肪测量和生物标志物之间的关系。正在进行的研究正在使用磁共振成像和认知评估对脑血管疾病进行广泛的评估。另一项平行研究是非裔美国人DHS，它扩大了非裔美国人的样本范围，以研究欧美人与非裔美国人在亚临床CVD中明显的种族差异。发展中的研究将评估在整个生命过程中社会压力对CVD风险的影响，以及这种富含糖尿病的样本中胃轻瘫的患病率。此外，DHS参与者持续的高死亡率也为2型糖尿病患者增加的风险提供了新颖的见解。目前正在使用全基因组关联研究（GWAS）方法对样品进行全面的遗传分析。这项来自GWAS调查的数据将补充以前基于家庭的连锁数据，以分析样本中多种性状的遗传因素。据我们所知，DHS研究系列创建了迄今可用的，经过最全面检查的2型糖尿病患者样本，并为2型糖尿病患者提供了独特的资源。这篇综述的目的是对DHS系列研究的主要结果进行总体概述，并将其与更大范围的糖尿病及其并发症的生物医学研究联系起来。

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