Spectroscopic Photoacoustic Molecular Imaging of Breast Cancer using a B7-H3-targeted ICG Contrast Agent

Katheryne E. Wilson; Sunitha V. Bachawal; Lotfi Abou-Elkacem; Kristen Jensen; Steven Machtaler; Lu Tian; Jürgen K. Willmann

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Spectroscopic Photoacoustic Molecular Imaging of Breast Cancer using a B7-H3-targeted ICG Contrast Agent

机译：使用B7-H3靶向的ICG造影剂对乳腺癌进行光谱光声分子成像

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Purpose: Breast cancer imaging methods lack diagnostic accuracy, in particular for patients with dense breast tissue, and improved techniques are critically needed. The purpose of this study was to evaluate antibody-indocyanine green (ICG) conjugates, which undergo dynamic absorption spectrum shifts after cellular endocytosis and degradation, and spectroscopic photoacoustic (sPA) imaging to differentiate normal breast tissue from breast cancer by imaging B7-H3, a novel breast cancer associated molecular target.

机译：目的：乳腺癌成像方法缺乏诊断准确性，特别是对于乳腺组织密集的患者，迫切需要改进技术。这项研究的目的是评估抗体-吲哚菁绿（ICG）偶联物，该偶联物在细胞内吞和降解后会发生动态吸收光谱移位，并通过光谱光声（sPA）成像通过对B7-H3成像来区分正常乳腺组织和乳腺癌，一种新型的乳腺癌相关分子靶标。

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《Theranostics》 |2017年第6期|共14页
作者
Katheryne E. Wilson; Sunitha V. Bachawal; Lotfi Abou-Elkacem; Kristen Jensen; Steven Machtaler; Lu Tian; Jürgen K. Willmann;
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中图分类医药、卫生;
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1. Affibody-Indocyanine Green Based Contrast Agent for Photoacoustic and Fluorescence Molecular Imaging of B7-H3 Expression in Breast Cancer [J] . Bam Rakesh, Laffey Makenna, Nottberg Katharine, Bioconjugate Chemistry . 2019,第6期

机译：基于乳腺癌B7-H3表达的光声和荧光分子成像的粘合剂 - 吲哚菁绿基造影剂
2. Molecular photoacoustic tomography of breast cancer using receptor targeted magnetic iron oxide nanoparticles as contrast agents [J] . Xi Lei, Grobmyer Stephen R., Zhou Guangyin, Journal of Biophotonics . 2014,第6期

机译：使用受体靶向磁性氧化铁纳米粒子作为造影剂的乳腺癌分子光声层析成像
3. Performance of near-infrared dyes as effective contrast agents for breast cancer detection through simulation of photoacoustic imaging [J] . A. Prabhakara Rao, Saugata Sinha Journal of Modern Optics . 2020,第4a6期

机译：近红外染料的性能作为乳腺癌检测的有效造影剂，通过模拟光声成像
4. Single wall carbon nanotube/bis carboxylic acid-ICG as a sensitive contrast agent for in vivo tumor imaging in photoacoustic tomography [C] . Saeid Zanganeh, Hai Li, Patrick D. Kumavor, Conference on photons plus ultrasound: imaging and sensing . 2013

机译：单壁碳纳米管/双羧酸-ICG作为光声层析成像中体内肿瘤成像的敏感造影剂
5. Molecular analysis of breast cancer utilizing tumor targeting ultrasound mechanical contrast agents [D] . Sakamoto, Jason H. 2005

机译：肿瘤靶向超声机械造影剂对乳腺癌的分子分析
6. Spectroscopic Photoacoustic Molecular Imaging of Breast Cancer using a B7-H3-targeted ICG Contrast Agent [O] . Katheryne E. Wilson, Sunitha V. Bachawal, Lotfi Abou-Elkacem, 2017

机译：使用B7-H3靶向的ICG造影剂对乳腺癌进行光谱光声分子成像
7. Affibody-Indocyanine Green Based Contrast Agent for Photoacoustic and Fluorescence Molecular Imaging of B7H3 Expression in Breast Cancer [O] . -1

机译：基于乳腺癌的B7H3表达的光声和荧光分子成像的亲自 - 吲哚菁绿基造影剂
8. Molecular MR Imaging of CD44 in Breast Cancer with Hyaluronan-Based Contrast Agents [R] . Artemov, D., Zhu, W. 2009

机译：基于透明质酸的造影剂对乳腺癌CD44的分子磁共振成像

Spectroscopic Photoacoustic Molecular Imaging of Breast Cancer using a B7-H3-targeted ICG Contrast Agent

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