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首页> 外文期刊>Therapeutic advances in psychopharmacology. >Enhancing adherence, subjective well-being and quality of life in patients with schizophrenia: which role for long-acting risperidone?
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Enhancing adherence, subjective well-being and quality of life in patients with schizophrenia: which role for long-acting risperidone?

机译：改善精神分裂症患者的依从性，主观幸福感和生活质量：长效利培酮具有哪些作用？

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This study evaluated adherence to treatment, quality of life and subjective well-being in patients with psychosis treated with long-acting injectable risperidone. Subjects enrolled were part of a larger study where patients were observed in an adherence to treatment program of the University of Rome Tor Vergata. A total of 27 nonadherent patients (21 men, six women; mean age: 36.1 years; range: 23–63 years) were enrolled. Maximum observational period was 30 months. A total of 12 patients were under treatment for 30 months (44.44%) but only nine had a valid 30-month follow up, while the remaining three patients initially treated at our unit continued long-acting risperidone at their local centre. Reductions of monthly mean values of Scale for the Assessment of Positive Symptoms (SAPS) [repeated measures analysis of variance (rm-ANOVA): p p p p 0.01) were observed. Significant differences with respect to SAPS baseline values from the sixth month, SANS baseline values from the seventh month, SWN baseline values from the eighth month, S-QoL baseline values from the eighteenth month were shown in post hoc tests. Reduction of SAPS mean values was associated with increase of SWN (p 0.0001) and S-QoL (p 0.0001) mean values as demonstrated by correlation analysis. The same inverse correlation was found between reduction of SANS mean values and increases of SWN (p 0.0001) and S-QoL (p = 0.0001) mean values. Long-term treatment with long-acting risperidone may be associated with improvement to adherence to therapy and quality of life. Patients may show improvement in psychopathological symptoms, subjective well-being and quality of life.
机译：这项研究评估了接受长效注射利培酮治疗的精神病患者对治疗的依从性，生活质量和主观幸福感。所招募的受试者是一项较大研究的一部分，在该研究中，观察到患者遵守罗马Tor Vergata大学的治疗计划。总共纳入了27位非依从性患者（男性21例，女性6例;平均年龄：36.1岁;范围：23-63岁）。最长观察期为30个月。共有12名患者接受了为期30个月的治疗（44.44％），但只有9名患者接受了有效的30个月随访，而其余3名最初在我们单位接受治疗的患者在其当地中心继续服用长效利培酮。观察到阳性症状评估量表（SAPS）的月平均值减少[方差的重复测量分析（rm-ANOVA）：p p p p 0.01）。在事后测试中显示了从第六个月开始的SAPS基线值，从第七个月开始的SANS基线值，从第八个月开始的SWN基线值，从第十八个月开始的S-QoL基线值的显着差异。相关分析表明，SAPS平均值的减少与SWN（p 0.0001）和S-QoL（p 0.0001）平均值的增加相关。在减少SANS平均值与增加SWN（p = 0.0001）和S-QoL（p = 0.0001）平均值之间发现了相同的反相关。长效利培酮的长期治疗可能与改善治疗依从性和生活质量有关。患者可能会表现出精神病理症状，主观幸福感和生活质量的改善。

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