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首页> 外文期刊>Therapeutic advances in cardiovascular disease. >Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue
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Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue

机译：人心房组织中血管紧张素-（1-12）/糜酶轴的差异表达

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Heart chymase rather than angiotensin converting enzyme has higher specificity for angiotensin (Ang) I conversion into Ang II in humans. A new pathway for direct cardiac Ang II generation has been revealed through the demonstration that Ang-(1-12) is cleaved by chymase to generate Ang II directly. We address here whether Ang-(1-12) and chymase gene expression and activity are detected in the atrial appendages of 44 patients (10 females) undergoing heart surgery for the correction of valvular heart disease, resistant atrial fibrillation or ischemic heart disease. Immunoreactive Ang-(1-12) expression was 54% higher in left atrial compared with right atrial appendages. This was associated with higher abundance of left atrial appendage chymase gene transcripts and chymase activity, but no differences in angiotensinogen mRNA. Atrial chymase enzymatic activity was highly correlated with left atrial but not right atrial enlargement as determined by echocardiography, while both tyrosine hydroxylase and neuropeptide Y atrial appendage mRNAs correlated with atrial angiotensinogen mRNAs. Higher Ang-(1-12) expression and upregulation of chymase gene transcripts and enzymatic activity from the atrial appendages connected to the enlarged left versus right atrial chambers of subjects with left heart disease defines a role of this alternate Ang II forming pathway in the processes accompanying adverse atrial and ventricular remodeling.
机译：心脏糜酶而不是血管紧张素转化酶对人类的血管紧张素（Ang）I转化为Ang II具有更高的特异性。通过证明糜酶Ang-（1-12）被裂解直接产生Ang II，揭示了直接产生心脏Ang II的新途径。我们在这里讨论是否在44例接受心脏手术以纠正瓣膜性心脏病，耐药性房颤或缺血性心脏病的患者（10名女性）的心耳中检测到Ang-（1-12）和糜酶基因的表达和活性。与右心耳相比，左心房的免疫反应性Ang-（1-12）表达高54％。这与左心耳糜酶基因转录物和糜酶活性较高，但血管紧张素原mRNA没有差异有关。通过超声心动图确定，心房糜酶的酶活性与左心房高度相关，而与右心房增大没有高度相关性，而酪氨酸羟化酶和神经肽Y心房附件mRNA与心房血管紧张素原mRNA相关。较高的Ang-（1-12）表达和食糜酶基因转录物的上调以及来自与患有左心脏病的受试者的左，右心房扩大连接的心耳的酶促活性定义了这种替代性Ang II形成途径在过程中的作用伴随不良的心房和心室重塑。

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