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Evaluation of experimental methods for nitric oxide release from cardiovascular implants; bypass grafts as an exemplar

机译：评价从心血管植入物中释放一氧化氮的实验方法;以旁路移植为例

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Background: There is a great potential for nitric oxide (NO) eluting biomaterials in biomedical applications. These include the development of cardiovascular implants, wound healing products, or applications in cancer and respiratory therapy. While the potential of these materials as a therapy is becoming clearer, the real-time monitoring of NO is not easy and the success in the development of such materials depends on the accurate quantification of NO release.Method: To emphasize on the importance of a measurement technique on the outcome of an experiment, we compared total NO released from S-nitroso-N-acetyl-d-penicillamine (SNAP) incorporated nanocomposite polymer in the form of bypass grafts under simulated physiological conditions using amperometric and chemiluminescence techniques.Results: We found that the total amount of NO measured by the amperometric technique was 35.8% of the theoretical amount. Similarly, on measuring NO release from the bypass grafts, we demonstrated that the chemiluminesence technique detected NO at a relatively higher level.Conclusions: The results of this study clearly demonstrate the relative difference between analysis techniques for accurate NO detection that can be applied to distinct experimental models associated with NO-eluting cardiovascular implants.
机译：背景：一氧化氮（NO）在生物医学应用中洗脱生物材料的潜力很大。这些包括开发心血管植入物，伤口愈合产品或在癌症和呼吸疗法中的应用。尽管这些材料作为疗法的潜力越来越明确，但对NO进行实时监测并不容易，开发这类材料的成功取决于对NO释放量的准确定量。方法：强调在一项实验结果的测量技术上，我们使用安培和化学发光技术，在模拟的生理条件下比较了以旁路接枝形式掺入的S-亚硝基-N-乙酰基-d-青霉胺（SNAP）纳米复合聚合物释放的总NO。我们发现，通过安培法测量的NO总量为理论量的35.8％。同样，在测量旁路移植物中的NO释放量时，我们证明了化学发光技术可在相对较高的水平上检测NO。结论：本研究结果清楚地表明了准确检测NO的分析技术之间的相对差异，可将其应用于与NO洗脱心血管植入物相关的实验模型。

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