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首页> 外文期刊>Therapeutic advances in cardiovascular disease. >Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage
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Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage

机译：依达拉奉，一种有效的自由基清除剂和钙通道阻滞剂，通过抑制氧化应激，细胞凋亡信号和超微结构损伤，减轻异丙肾上腺素诱发的心肌梗塞

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In the present study, we investigated whether combination therapy of low-dose benidipine with the potent free radical scavenger edaravone has a cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (MI) in Wistar rats. Rats were pretreated with concurrent doses of benidipine and edaravone (1 μg/kg/day + 1 mg/kg/day and 3 μg/kg/day + 3 mg/kg/day) by intravenous (i.v.) and intraperitoneal (i.p.) routes respectively for 28 days, followed by MI induction using ISO (85 mg/kg) by subcutaneous route for two days at 24 h intervals. After the treatment period, blood was withdrawn and the heart was preserved for biochemical estimations. The activities of the cardiac biomarkers (lactate dehydrogenase and creatine kinase-MB), and the level of malondialdehyde (MDA) significantly increased, while antioxidant markers (reduced glutathione, catalase, superoxidase dismutase, glutathione peroxidase, glutathione reductase) were significantly decreased in the ISO intoxicated group compared with the control group. Moreover, the level of C-reactive protein (CRP) and Caspase-3 activity significantly increased in ISO-intoxicated group. An ultrastructure study was also carried out. Pretreatment with a combination of benidipine and edaravone significantly attenuated the activities of the cardiac biomarkers and the level of MDA, and significantly increased the antioxidant markers compared with the ISO-intoxicated group. Furthermore, pretreatment with the combination of benidipine and edaravone significantly decreased the level of CRP and Caspase-3 activity as compared to the ISO-treated group. The ultrastructure study of myocardium revealed that pretreated groups preserved the mitochondrial shape, the membrane and its internal structures. Taken together these results suggest that the combination of benidipine and edaravone showed significant protective effect in ISO-induced MI.
机译：在本研究中，我们调查了低剂量贝尼地平与有效的自由基清除剂依达拉奉的联合治疗是否对Wistar大鼠中异丙肾上腺素（ISO）诱发的心肌梗塞（MI）具有心脏保护作用。通过静脉内（iv）和腹膜内（ip）途径同时给予贝尼地平和依达拉奉（1μg/ kg /天+ 1 mg / kg /天和3μg/ kg /天+ 3 mg / kg /天）进行预处理分别持续28天，然后以24小时间隔通过皮下途径使用ISO（85 mg / kg）进行MI诱导2天。治疗期后，抽血并保存心脏用于生化评估。心脏生物标志物的活性（乳酸脱氢酶和肌酸激酶-MB）和丙二醛（MDA）水平显着增加，而抗氧化剂标志物（还原型谷胱甘肽，过氧化氢酶，过氧化物酶歧化酶，谷胱甘肽过氧化物酶，谷胱甘肽还原酶）显着降低。 ISO中毒组与对照组相比。此外，在ISO中毒组中，C反应蛋白（CRP）和Caspase-3活性水平显着增加。还进行了超微结构研究。与ISO中毒组相比，贝尼地平和依达拉奉的联合预处理可显着减弱心脏生物标志物的活性和MDA水平，并显着增加抗氧化剂标志物。此外，与ISO治疗组相比，贝尼地平和依达拉奉的组合预处理显着降低了CRP和Caspase-3活性水平。心肌的超微结构研究表明，预处理组保留了线粒体的形状，膜及其内部结构。综合这些结果表明，贝尼地平和依达拉奉的组合在ISO诱导的MI中显示出显着的保护作用。

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