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首页> 外文期刊>Therapeutic advances in psychopharmacology. >Prescribing pattern of clozapine and other antipsychotics for patients with first-episode psychosis: a cross-sectional survey of early intervention teams
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Prescribing pattern of clozapine and other antipsychotics for patients with first-episode psychosis: a cross-sectional survey of early intervention teams

机译：初发精神病患者的氯氮平和其他抗精神病药的处方模式：早期干预小组的横断面调查

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To describe the pattern of antipsychotic drug prescribing in patients with first episode psychosis, with more emphasis in the use of clozapine in this group of patients. A cross-sectional survey involving six early intervention service (EIS) teams in the West Midlands was conducted. Data was extracted from case notes and electronic records by clinicians working in each participating team. The pattern of antipsychotic prescribing and the changes that took place after being accepted in EIS, including the use of clozapine, was established. Clinicians involved in the treatment of patients in each team rated the overall clinical response to treatment based on the presence or absence of positive psychotic symptoms. 431 patients with FEP were included in the final analysis. Low antipsychotic discontinuation rate was observed, with the majority (88.2%) still being prescribed antipsychotics. Most (77.3%) were prescribed second-generation antipsychotic drugs, with olanzapine (21.8%) and aripiprazole (19.7%) being the most frequently prescribed antipsychotics. There was low rate use of antipsychotic combinations (7.4%), high dose antipsychotic regime (3.9%), low depot antipsychotic prescribing (9.3%), and clozapine use was low (9.7%). On average, three antipsychotics were tried before clozapine was initiated and it took on average 19.5 months from being accepted into EIS to clozapine being initiated. The majority of patients were prescribed antipsychotics within the guidelines. EIS was associated with an overall low antipsychotic discontinuation. There was also a short waiting time before clozapine was initiated following patients being accepted into EIS.
机译：描述首发性精神病患者的抗精神病药物处方模式，在此组患者中更强调氯氮平的使用。对西米德兰兹郡的六个早期干预服务（EIS）团队进行了横断面调查。每个参与小组中的临床医生均从病例笔记和电子记录中提取数据。建立了抗精神病药物处方的模式以及被EIS接受后发生的变化，包括使用氯氮平。每个小组中涉及患者治疗的临床医生根据是否存在阳性精神病症状来评估对治疗的总体临床反应。最终分析包括431名FEP患者。观察到抗精神病药物停用率低，大多数（88.2％）仍是处方抗精神病药物。大多数（77.3％）被处方开了第二代抗精神病药物，其中奥氮平（21.8％）和阿立哌唑（19.7％）是最经常开处方的抗精神病药物。使用抗精神病药物的比例较低（7.4％），使用大剂量抗精神病药物的比例（3.9％），低库抗精神病药物处方的比例（9.3％），氯氮平的使用率较低（9.7％）。在开始服用氯氮平之前，平均尝试了三种抗精神病药物，从接受EIS到开始服用氯氮平平均需要19.5个月的时间。在指南中，大多数患者都开了抗精神病药。 EIS与总体低抗精神病药物停用有关。患者入院EIS后开始氯氮平的等待时间也很短。

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