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首页> 外文期刊>Therapeutic advances in cardiovascular disease. >Atropine first is safer than conventional atropine administration in older people undergoing dobutamine stress echocardiography
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Atropine first is safer than conventional atropine administration in older people undergoing dobutamine stress echocardiography

机译：对于接受多巴酚丁胺负荷超声心动图检查的老年人，首先使用阿托品比常规阿托品更安全

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Early injection of atropine during dobutamine stress echocardiography (DSE) has been demonstrated in retrospective analyses to reduce the duration and dose of dobutamine infusion, while preserving a similar diagnostic accuracy with a lower incidence of adverse effects. This study explores the safety of using atropine as a start drug before dobutamine infusion (ADSE protocol) in comparison with the conventional protocol (DASE protocol) in older patients undergoing DSE for ischemia evaluation. One hundred consecutive older patients were prospectively enrolled. When eligible, they were randomly assigned to undergo either the DASE protocol (group A, 50 patients) or the ADSE protocol (group B, 50 patients) when atropine (1.0 mg) was first administered 3 min before dobutamine infusion followed by 0.5 mg increments (maximum 1.0 mg) thereafter. Patients were monitored for adverse drug effects. Test duration was calculated. The mean age of the whole study cohort was 67.8 ± 4.3 years and 58 (58%) were men. Patients in group A had longer test duration (21.8 ± 1.3 versus 13.7 ± 0.77 min, p versus 28.2 ± 9.5 μg/kg/min, p p In older patients undergoing DSE, using atropine as a start drug, that is, adopting the ADSE protocol, is associated with shorter test duration, lower mean dobutamine infusion rate and consequently fewer adverse effects.
机译：回顾性分析表明，在多巴酚丁胺负荷超声心动图检查（DSE）期间早期注射阿托品可减少多巴酚丁胺输注的持续时间和剂量，同时保持相似的诊断准确性，且不良反应的发生率较低。这项研究探讨了在接受DSE进行缺血评估的老年患者中，与传统方案（DASE方案）相比，在多巴酚丁胺输注（ADSE方案）之前使用阿托品作为起始药物的安全性。前瞻性招募了一百名连续的老年患者。如果符合条件，当在多巴酚丁胺输注前3分钟首次服用阿托品（1.0 mg）时，将他们随机分配为接受DASE方案（A组，50名患者）或ADSE方案（B组，50名患者） （最大1.0毫克）之后。监测患者的药物不良反应。计算测试持续时间。整个研究队列的平均年龄为67.8±4.3岁，男性为58（58％）。 A组患者的测试时间更长（21.8±1.3 vs 13.7±0.77 min，p vs 28.2±9.5μg/ kg / min，pp在进行DSE的老年患者中，使用阿托品作为起始药物，即采用ADSE方案，与较短的测试持续时间，较低的平均多巴酚丁胺输注速率相关，因此不良反应较少。

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