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首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >Cross-sectional correlates of increased IL-18 but reduced fetuin-A and oxytocin with adiposity and blood indices in metabolic syndrome patients with and without prediabetes
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Cross-sectional correlates of increased IL-18 but reduced fetuin-A and oxytocin with adiposity and blood indices in metabolic syndrome patients with and without prediabetes

机译：患有和不患有前驱糖尿病的代谢综合征患者中IL-18升高但胎球蛋白A和催产素降低与肥胖和血液指数的横断面相关性

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Oxytocin (OXT), fetuin-A and interleukin-18 (IL-18) are involved in the development and progression of metabolic syndrome (MetS) and prediabetes (pre/T2DM). This study aimed to compare and correlate the plasma levels of OXT, fetuin-A and IL-18 with clinical parameters, haematological indices and adiposity indices in Jordanian MetS subjects. In a cross-sectional study, 30 normoglycaemic lean study participants (control), 30 MetS study participants, and 29 MetS pre/T2DM study participants were recruited. Median circulating levels of both OXT and fetuin-A were lower in MetS and MetS pre/T2DM versus control group. OXT (pg/ml; median interquartile range): MetS 1975.4 and MetS pre/T2DM 1403 versus control 4176.6 (p = 0.009 and p = 0.001, respectively). For fetuin-A (ng/ml), MetS (5784) and MetS pre/T2DM (2154) were lower versus control (6756.3) (p = 0.040 and p = 0.007, respectively). Neither biomarker was described as substantially different in MetS versus MetS pre/T2DM (p = 0.071 and p = 0.155, respectively). Conversely, a non-significant increase in IL-18 was observed in the MetS and MetS pre/T2DM groups compared to normoglycaemic lean controls (232 and 287.5, p 0.05 versus 108 for both). In addition, conicity index (C-index), atherogenicity index (TG-HDL-C), waist to hip ratio, mean platelet volume (MPV; fl) and red cell distribution width (RDW-CV%) in both MetS and MetS pre/T2DM were significantly higher (p versus controls. However all above MetS-related indices were not ascribed any statistically marked variation in the MetS group when compared to the MetS pre/T2DM group. Both total study pool of recruits’ fetuin-A (Spearman r = –2.66, p = 0.049) as well as MetS pre/T2DM group IL-18 (Spearman r = 0.380, p = 0.046) were inversely correlated with RDW-CV%. OXT in MetS inversely correlated with waist circumference/hip circumference ratio (Spearman r = ?0.387, p = 0.038). No other pronounced associations between biomarkers could be detected in any study arm. These findings substantiate the clinical relevance and significance of OXT, fetuin-A and IL-18 as surrogate screening/prognostic tools and therapeutic targets to predict/prevent metabolic dysregularities and anomalies.
机译：催产素（OXT），胎球蛋白A和白介素18（IL-18）参与代谢综合征（MetS）和糖尿病前期（pre / T2DM）的发生和发展。这项研究旨在比较约旦人MetS受试者的OXT，胎球蛋白A和IL-18的血浆水平与临床参数，血液学指标和肥胖指数。在一项横断面研究中，招募了30名正常血糖瘦身研究参与者（对照），30名MetS研究参与者和29名MetS pre / T2DM研究参与者。与对照组相比，MetS和MetS pre / T2DM中的OXT和胎球蛋白A的中位循环水平较低。 OXT（pg / ml;中位数四分位间距）：MetS 1975.4和MetS pre / T2DM 1403与对照4176.6（分别为p = 0.009和p = 0.001）。对于胎球蛋白A（ng / ml），MetS（5784）和MetS pre / T2DM（2154）比对照（6756.3）低（分别为p = 0.040和p = 0.007）。 MetS与MetS pre / T2DM相比，两种生物标记物均无显着差异（分别为p = 0.071和p = 0.155）。相反，与正常血糖瘦对照相比，在MetS和MetS pre / T2DM组中观察到IL-18的无显着增加（两者均为232和287.5，p> 0.05对108）。此外，在MetS和MetS中，锥度指数（C-index），动脉粥样硬化指数（TG-HDL-C），腰臀比，平均血小板体积（MPV; fl）和红细胞分布宽度（RDW-CV％） pre / T2DM明显高于对照组（p与对照组。但是，与MetS pre / T2DM组相比，MetS组中所有以上与MetS相关的指标均无统计学上显着的差异。） Spearman r = –2.66，p = 0.049）以及MetS pre / T2DM组IL-18（Spearman r = 0.380，p = 0.046）与RDW-CV％成反比，MetS中的OXT与腰围/臀围成反比。周长比（Spearman r = 0.387，p = 0.038）在任何研究组中均未检测到其他生物标志物之间的明显关联，这些发现证实了OXT，胎球蛋白-A和IL-18的临床相关性和意义作为替代筛查/预测/预防代谢异常和异常的预后工具和治疗目标。

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