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首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >Managing congenital hypogonadotrophic hypogonadism: a contemporary approach directed at optimizing fertility and long-term outcomes in males
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Managing congenital hypogonadotrophic hypogonadism: a contemporary approach directed at optimizing fertility and long-term outcomes in males

机译：管理先天性性腺功能减退性性腺功能减退症：一种当代方法，旨在优化男性的生育力和长期结局

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摘要

Hormonal induction of spermatogenesis offers men with azoospermia due to hypogonadotrophic hypogonadism (HH) the promising prospect of fertility restoration. However, an important exception is the subset of individuals affected by congenital hypogonadotrophic hypogonadism (CHH), also known as Kallmann syndrome if associated with anosmia, who often display dismal responses to fertility induction, despite prolonged therapy. This primarily stems from the loss of minipuberty, which is a crucial phase of testicular maturation in early life that has a far-reaching impact on eventual spermatogenic capacity. Further exacerbating the compromised reproductive health is the failure to initiate timely pubertal induction in many CHH patients, resulting in suboptimal genital and psychosexual development. In this paper, the clinical implications and management of male HH across the lifespan is comprehensively reviewed, with a special focus on novel strategies that have the potential to modify disease severity and maximize fertility potential in CHH by addressing the inadequacies of conventional approaches.
机译：激素诱导的精子生成使男性由于性腺功能减退性性腺机能减退（HH）而无精子症，有望恢复生育能力。然而，一个重要的例外是受先天性性腺功能减退性腺功能减退症（CHH）影响的个体的子集，如果伴有失眠症，也被称为Kallmann综合征，尽管治疗时间长，但对生育力的诱导往往表现出令人沮丧的反应。这主要是由于青春期的丧失，青春期的丧失是早期睾丸成熟的关键阶段，对最终的生精能力具有深远的影响。在许多CHH患者中，未能及时启动青春期诱导，导致生殖健康受到损害，这导致生殖器和心理性生殖发育欠佳。在本文中，对男性HH在整个生命周期中的临床意义和管理进行了全面的综述，特别关注了通过解决传统方法的不足之处，有可能改变CHH疾病严重程度并最大化生育潜力的新策略。

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