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Therapeutic benefits of budesonide in gastroenterology

机译：布地奈德在胃肠病学中的治疗益处

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Budesonide is a synthetic steroid of the glucocorticoid family with a high topical antiinflammatory activity. Enteric-coated formulations resist gastric-acid degradation, delivering active drug to the small intestine and proximal colon. Budesonide has a high first-pass metabolism with minimal systemic absorption. It is therefore felt to cause fewer side effects than traditional glucocorticosteroids and to be generally well tolerated. The aim of this paper is to examine the utility of this medication in frequently encountered gastrointestinal conditions: Crohn’s disease, ulcerative colitis, microscopic colitis and eosinophilic oesophagitis. A Medline search was performed to find published original research and review articles relating to the use budesonide in common gastroenterological conditions. The results showed that budesonide is efficacious in the induction and short-term maintenance of Crohn’s disease. Budesonide is the best-documented treatment for microscopic colitis. It is well proven to be effective in the induction of remission in collagenous colitis but its use in lymphocytic colitis remains less well documented. In conclusion, budesonide is an effective glucocorticosteroid therapy for many chronic gastrointestinal diseases. In combination with its efficacy, the low incidence of serious side effects associated with this drug should keep it at the forefront in the therapeutic arsenal of any gastroenterologist.
机译：布地奈德是糖皮质激素家族的合成类固醇，具有较高的局部抗炎活性。肠溶制剂可抵抗胃酸降解，将活性药物输送至小肠和近端结肠。布地奈德具有较高的首过代谢，且全身吸收最少。因此，与传统的糖皮质类固醇相比，它引起的副作用更少，并且通常具有良好的耐受性。本文的目的是研究这种药物在胃肠道疾病中的应用：克罗恩病，溃疡性结肠炎，显微镜性结肠炎和嗜酸性食管炎。进行了Medline搜索，以查找已发表的原始研究成果和评论文章，这些文章涉及在常见肠胃疾病中使用布地奈德。结果表明布地奈德在克罗恩病的诱导和短期维持方面有效。布地奈德是微观结肠炎的最佳文献报道。业已证明，它可有效诱导胶原性结肠炎的缓解，但在淋巴细胞性结肠炎中的使用仍缺乏文献记载。总之，布地奈德对许多慢性胃肠道疾病是一种有效的糖皮质激素治疗。结合其功效，与这种药物相关的严重副作用的低发生率应使它保持在任何胃肠病医生治疗武库中的前列。

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