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首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with subclinical hypothyroidism
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Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with subclinical hypothyroidism

机译：亚临床甲状腺功能减退症患者的Tp-e间隔，Tp-e / QT比和Tp-e / QTc比的评估

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Prolongation of the peak-to-end interval of the T wave (Tp-e) has been reported as associated with ventricular arrhythmias. The aim of this study was to investigate the ventricular repolarization by using the Tp-e interval, Tp-e/QT ratio and Tp-e/ QTc ratio in patients with subclinical hypothyroidism (SH). We studied 56 volunteers: These were 28 patients with SH (mean age 45 ± 11 years) and 28 healthy subjects (mean age 34 ± 8 years). All basic biochemical parameters were analyzed and electrocardiograms (ECGs) were recorded. RR and QT intervals, QTc, Tp-e intervals and the Tp-e/QT and Tp-e/QTc ratios were calculated. The categorical and numerical variables were compared using the chi-square test and independent t test, respectively. Correlations were analyzed using the Spearman and Pearson correlation tests. We found no difference between QT and QTc intervals between groups. In the subjects with SH, the Tp-e intervals (87 ± 5 ms, 66 ± 5 ms, p 0.01), Tp-e/ QT ratio (0.23 ± 0.03, 0.18 ± 0.01, p 0.01) and Tp-e/QTc ratio (0.21 ± 0.02, 0.16 ± 0.01, p 0.01) were increased compared with healthy subjects. We also found positive correlations between levels of thyroid stimulating hormone (TSH) and Tp-e (r = 0.72, p 0.01), Tp-e/ QT ratio (r = 0.67 p 0.01), Tp-e/ QTc ratio (r = 0.68, p 0.01). In the subjects with SH, Left Ventricular Myocardial Performance Index (LV-MPI) was increased compared with the healthy subjects (0.64 ± 0.08, 0.59 ± 0.09, p = 0.066) although it was not significant. Compared with healthy subjects, patients with SH demonstrated longer Tp-e intervals, and higher Tp-e/QT and Tp-e/QTc ratios. TSH levels were positively correlated with Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio.
机译：据报道，T波峰-末间隔的延长（Tp-e）与室性心律失常有关。这项研究的目的是通过使用Tp-e间隔，Tp-e / QT比和Tp-e / QTc比来研究亚临床甲状腺功能减退症（SH）患者的心室复极。我们研究了56名志愿者：28名SH患者（平均年龄45±11岁）和28名健康受试者（平均年龄34±8岁）。分析所有基本生化参数并记录心电图（ECG）。计算RR和QT间隔，QTc，Tp-e间隔以及Tp-e / QT和Tp-e / QTc比。分别使用卡方检验和独立t检验比较类别变量和数值变量。使用Spearman和Pearson相关检验分析相关性。我们发现组之间的QT和QTc间隔之间没有差异。在患有SH的受试者中，Tp-e间隔（87±5 ms，66±5 ms，p 0.01），Tp-e / QT比（0.23±0.03，0.18±0.01，p 0.01）和Tp-e / QTc与健康受试者相比，比率（0.21±0.02，0.16±0.01，p 0.01）增加。我们还发现甲状腺刺激激素（TSH）水平与Tp-e（r = 0.72，p 0.01），Tp-e / QT比（r = 0.67 p 0.01），Tp-e / QTc比（r = 0.68，p 0.01）。与健康受试者相比，SH受试者的左心室心肌性能指数（LV-MPI）升高（0.64±0.08，0.59±0.09，p = 0.066），尽管不显着。与健康受试者相比，SH患者表现出更长的Tp-e间隔，以及更高的Tp-e / QT和Tp-e / QTc比。 TSH水平与Tp-e间隔，Tp-e / QT比和Tp-e / QTc比呈正相关。

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